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| ID | Type | Description | Link |
|---|---|---|---|
| ChiCTR-OOC-16009006 | Registry Identifier | Chinese Clinical Trial Registry |
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Study on the registration of coronary heart disease patients undergoing PCI in Chinese's population. Get the incidence of adverse events in these patients after PCI, a clear type of adverse reaction, forms, influencing factors, to establish risk management processes, clinical safety and reasonable treatment, and provide the basis for further research and reference.
Dual antiplatelet therapy, comprising a low-dose aspirin and a kind of P2Y12 Receptor Inhibitors, has been the mainstay of the management in patients with acute coronary syndromes and/or undergoing Percutaneous Coronary Intervention (PCI). While variability to P2Y12 receptor inhibitors is common in patients and is a major cause of adverse cardiovascular events. Low response to P2Y12 receptor inhibitors will result high platelet reactivity (HPR) and patients who exhibit HPR are at increased risk of atherothrombotic occlusion events. Vice versa, high response to P2Y12 receptor inhibitors will lead to low platelet reactivity (LPR) and increase the risk of hemorrhage.Now, the absence of a universal definition of therapeutic window for different racial and actual clinical situations and lacking the gold standard test to quantify it limit the use in clinic practice.So this clinical trial try to use patient's platelet reactivity combine with type of adverse reaction, forms, influencing factors to find a proper therapeutic windows for P2Y12 receptor inhibitors in Chinese people.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| antiplatelet agents(Clopidogrel or Ticagrelor) | Drug | Clinical physicians according to patients condition to give different antiplatelet agents(Clopidogrel or Ticagrelor).We only observe clinical curative effect. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Major adverse cardiovascular events | ischemic and bleeding | within 1 year after PCI |
| Measure | Description | Time Frame |
|---|---|---|
| Blood drug concentration | Clopidogrel and Ticagrelor | at 5-7 days, 1month, 3 months, 6 months and 12 months after taking anti-platelet agents |
| Mild to moderate adverse events | renal function |
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Inclusion Criteria:
Exclusion Criteria:
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patients with coronary artery disease treated with aspirin and clopidogrel after successful stent implantation.
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| Name | Affiliation | Role |
|---|---|---|
| GuoPing Yang, professor | The Third Xiangya Hospital of Central South University | Principal Investigator |
| Yu Cao, MD | The Third Xiangya Hospital of Central South University | Principal Investigator |
| Jingle Li, MD | The Third Xiangya Hospital of Central South University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Third Xiangya Hospital of Central South University | Changsha | Hunan | 410013 | China |
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| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D000077486 | Ticagrelor |
| D000077144 | Clopidogrel |
| ID | Term |
|---|---|
| D000241 | Adenosine |
| D011684 | Purine Nucleosides |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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gene test
| within 1 year after PCI |
| Platelet activity | Platelet activity | at 12- 24 hours, 1 month, 3 months, 6 months and 12 months after PCI |
| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D009705 | Nucleosides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012263 | Ribonucleosides |
| D013988 | Ticlopidine |
| D058924 | Thienopyridines |
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |