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Pathophysiology of polymyalgia rheumatica (PMR) is ill defined. This study aims at characterizing immunological abnormalities in PMR patients, and to assess the effects of tocilizumab therapy on this abnormalities.
Comparison of PMR patients and matched control subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PMR patients | Patients included in the clinical trial TENOR (prospective open-labeled study of tocilizumab in treatment-naïve PMR patients) |
| |
| Healthy controls | Matched to PMR patients for sex and age, exclusion of any autoimmune, inflammatory, neoplastic and chronic infectious disease |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tocilizumab | Drug | 3 monthly IV infusions in PMR patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of blood lymphocyte populations (T cells, B cells, NK cells) | Lymphocyte subset analysis by flow cytometry | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Serum cytokine concentration measurement | Cytokine level measurements using an array and ELISAs | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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PMR patients included in the TENOR study (NCT01713842).
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| Name | Affiliation | Role |
|---|---|---|
| Divi Cornec | CHRU de Brest | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU de Brest | Brest | 29609 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26929219 | Background | Devauchelle-Pensec V, Berthelot JM, Cornec D, Renaudineau Y, Marhadour T, Jousse-Joulin S, Querellou S, Garrigues F, De Bandt M, Gouillou M, Saraux A. Efficacy of first-line tocilizumab therapy in early polymyalgia rheumatica: a prospective longitudinal study. Ann Rheum Dis. 2016 Aug;75(8):1506-10. doi: 10.1136/annrheumdis-2015-208742. Epub 2016 Feb 29. |
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| ID | Term |
|---|---|
| D011111 | Polymyalgia Rheumatica |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
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| ID | Term |
|---|---|
| C502936 | tocilizumab |
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Serum
| D017437 | Skin and Connective Tissue Diseases |