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The purpose of this study is to determine whether low protein diet and very low protein diet supplemented keto-/amino acid is effective in preventing the progression of chronic kidney disease (CKD , stage 2 to 5).
Dietary protein restriction represents a basic therapeutic approach in chronic kidney disease(CKD), by reducing the accumulation of nitrogen catabolic substances, and by delaying the progress of CKD and proteinuria, but the effects of the low protein diet on renal failure progression rate remain to be determined.The aim of this study is to evaluate the efficacy of low protein diet and α-keto acid tablet in retard the progress of CKD. This is a prospective study, 100 patients who meet inclusion and exclusion criteria will be included. The changes of glomerular filtration rate in CKD and time to renal replacement will be evaluated after 1 year treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| low protein diet plus α-keto acid | Experimental | A comparison of normal diet and low protein diet plus α-keto acid after intervention in the same individual |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| low protein diet plus α-keto acid | Behavioral | 0.4-0.6g of proteins per kilo of body weight per day, supplemented with α-keto acid tablets |
|
| Measure | Description | Time Frame |
|---|---|---|
| changes in glomerular filtration rate | Nutritional status, evaluated by nutrition risk screening (NRS 2002), at the start and during the 1st year of investigators' intervention. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Compliance to diet | Compliance to diet, defined by the participants' persistence in low protein diet, by outpatient follow-up and telephone follow-up. | 1 year |
| Nutritional status | Nutritional status, evaluated by nutrition risk screening (NRS 2002), at the start and during the 1st year of investigators' intervention. |
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Inclusion Criteria: Patients with chronic kidney disease in stage 2 to 5 (GFR<60 ml/min/1.73m2) receiving conservative treatment for CKD
Exclusion Criteria: None
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Min Liu, M.D. | Contact | 86-731-88618717 | liumin330@hotmail.com | |
| Meng Wang, M.M. | Contact | 86-731-88618717 | znxywm@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Min Liu, M.D. | specify unaffiliated | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the Third Xiangya Hospital of Central South University | Recruiting | Changsha | Hu'nan | 410013 | China |
During the experiment, investigators will share the development in the website.
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D018753 | Diet, Protein-Restricted |
| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
| D004032 | Diet |
| D009747 |
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|
| 1 year |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |