Limbal Stem Cell Deficiency of Genetic Origin: Genotype-p... | NCT02886611

Studies
Limbal Stem Cell Deficiency of Genetic Origin: Genotype-phenotype Correlation

NCT02886611

Sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Status

Recruiting

Last Update Posted

Dec 3, 2025Actual

Enrollment

60Estimated

Phase

Not provided

Conditions

Limbus Corneae

Interventions

Not provided

Countries

France

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Dec 2025

Overall Recruitment Status or Expanded Access Status

Recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Dec 15, 2015Actual

Primary Completion Date

Dec 2025Estimated

Completion Date

Dec 2026Estimated

First Submitted Date

Aug 29, 2016

First Submission Date that Met QC Criteria

Aug 29, 2016

First Posted Date

Sep 1, 2016Estimated

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Dec 2, 2025

Last Update Posted Date

Dec 3, 2025Actual

Description Module

Brief Summary

The study aims at searching for a genotype-phenotype correlation in patients with a genetic pathology of the ocular surface, in order to identify genetic abnormalities associated with the most severe clinical situations.

Detailed Description

Not provided

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

No data available

No data is available for this block.

Enrollment

60Estimated

Measure	Description	Time Frame
Genotype-phenotype Correlation		baseline

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

genetic pathology of ocular surface

Exclusion Criteria:

Agonal glaucoma
Low vision mostly related to retinal pathology
Pregnant or breast feeding patient

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

Not provided

Maximum Age

Not provided

Standard Ages

ChildAdultOlder Adult

Study Population

Patients with decreased visual acuity of corneal origin will be selected and genetic analysis will be performed.

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Name	Role	Phone	Extension	Email
Amélie YAVCHITZ, MD, PhD	Contact	0033148036454		ayavchitz@for.paris

Overall Officials

Name	Affiliation	Role
Anna GEMAHLING, MD	Hôpital Fondation Adolphe de Rothschild	Principal Investigator
Eric GABISON, MD	Hôpital Bichat (AP-HP)	Principal Investigator
Dominique BREMOND-GIGNAC, MD

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Fondation Ophtalmologique Adolphe de Rothschild	Recruiting	Paris		75019	France