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This study will evaluate patient comfort and oxygen delivery efficiency when providing supplemental oxygen through a nasal cannula to volunteers using an instrumented oxygen delivery system. The goals of the study are to evaluate different oxygen flow rates and oxygen delivery modes. In addition, the investigators will investigate if the system can detect apnea (cessation of breathing) and removal of the nasal cannula. The investigators will also investigate how well high flow oxygen delivered only during inspiration is tolerated and how much the end-tidal oxygen increases after two minutes of high oxygen flow delivered only during the inhalation phase of the breath.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Supplemental Oxygen Delivery System | Device |
| Measure | Description | Time Frame |
|---|---|---|
| End-tidal Oxygen | Did the novel system increase end-tidal oxygen? | Continuously throughout 30 minute volunteer study |
| Patient Comfort | Did the patients feel it was more comfortable for a given end-tidal oxygen level? | Every 2 minutes up to 30 minutes |
| End-tidal Carbon Dioxide | Was end-tidal carbon dioxide measured more accurately using the novel system? | Continuously throughout 30 minute volunteer study |
| Respiratory Rate | Compared respiratory rate against capnometry. | Continuously throughout 30 minute volunteer study |
| Oxygen Saturation | Did the novel system increase oxygen saturation? | Continuously throughout 30 minute volunteer study |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy volunteers drawn from the general public and students, staff, and faculty of the University of Utah.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Utah | Salt Lake City | Utah | 84112 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19294365 | Background | Chanques G, Constantin JM, Sauter M, Jung B, Sebbane M, Verzilli D, Lefrant JY, Jaber S. Discomfort associated with underhumidified high-flow oxygen therapy in critically ill patients. Intensive Care Med. 2009 Jun;35(6):996-1003. doi: 10.1007/s00134-009-1456-x. Epub 2009 Mar 18. | |
| 14656787 | Background | Sasaki H, Yamakage M, Iwasaki S, Mizuuchi M, Namiki A. Design of oxygen delivery systems influences both effectiveness and comfort in adult volunteers. Can J Anaesth. 2003 Dec;50(10):1052-5. doi: 10.1007/BF03018373. |
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| 30633057 | Derived | Burk KM, Sakata DJ, Kuck K, Orr JA. Comparing Nasal End-Tidal Carbon Dioxide Measurement Variation and Agreement While Delivering Pulsed and Continuous Flow Oxygen in Volunteers and Patients. Anesth Analg. 2020 Mar;130(3):715-724. doi: 10.1213/ANE.0000000000004004. |