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Abatacept disrupts T-cell coactivation signals in rheumatoid arthritis (RA). Its potential effects on B cells are not well described. This study will assess the effects of abatacept therapy on the phenotype and function of peripheral blood B cells in patients with RA.
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| Measure | Description | Time Frame |
|---|---|---|
| Peripheral blood B-cell phenotype changes | Measure of the proportion of the main B-cell subsets (transitional, naïve, memory, plasmablasts) by FACS analysis before abatacept initiation and 3 months later. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| In vitro B-cell function and regulatory properties | In vitro culture of B cells from the patients to assess B cell inhibition of T cell proliferation before abatacept initiation and 3 months later. | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with RA fulfilling ACR/EULAR criteria, in whom abatacept is started as part of their usual clinical care
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| Name | Affiliation | Role |
|---|---|---|
| Jacques-Olivier Pers | CHRU de Brest | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU de Brest | Brest | 29609 | France |
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| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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Serum
| D003240 |
| Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |