Impact of Subthalamic Nucleus Deep Brain Stimulation on Pain in Parkinson Disease

Impact of Subthalamic Nucleus Deep Brain Stimulation on Pain in Parkinson Disease : Clinical and Neurophysiological Study

Pain is a common symptom of Parkinson's disease (PD) but the physiology remains poorly understood. Recent work suggests that subthalamic nucleus deep brain stimulation (STN-DBS) could make a profit on the pain in PD.

The investigator would drive a study with a follow up of PD patients before and after STN-DBS. The pain will be clinically explored by targeted questionnaires and electrophysiological through laser evoked potentials.

The questionnaires are designed to quantify and characterize the pain in these patients. Laser evoked potentials will, through repetitive stimulation, study both the functional status of the afferent nociceptive pathways, their habituation to repetitive nociceptive stimuli, and so better understand any abnormalities of the central processing of nociceptive information.

Inclusion Criteria:

• A patient with idiopathic Parkinson's disease
• Age between 30 and 70 inclusive.
• No cognitive decline (MMS greater than or equal to 24)
• Normal brain MRI
• Informed consent signed
• With or without pain sensation

Exclusion Criteria:

• Presence of other neurological pathology that could explain the pain.
• MMS less than 24
• Pregnant or breastfeeding women