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Pain is a common symptom of Parkinson's disease (PD) but the physiology remains poorly understood. Recent work suggests that subthalamic nucleus deep brain stimulation (STN-DBS) could make a profit on the pain in PD.
The investigator would drive a study with a follow up of PD patients before and after STN-DBS. The pain will be clinically explored by targeted questionnaires and electrophysiological through laser evoked potentials.
The questionnaires are designed to quantify and characterize the pain in these patients. Laser evoked potentials will, through repetitive stimulation, study both the functional status of the afferent nociceptive pathways, their habituation to repetitive nociceptive stimuli, and so better understand any abnormalities of the central processing of nociceptive information.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients who underwent Deep Brain Stimulation (DBS) | Other | Patients who underwent Subthalamic Nucleus (STN)-DBS at Lyon |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laser-Evoked potential | Other | Laser-Evoked potential can document lesions of spinothalamic tract and lateral brainstem and of thalamo-cortical projections conducting nociceptive signals. The rapid heating of skin by infrared laser pulses stimulate small fibers sensory pathways. The main cortical laser evoked potential is a complex of components N2-P2. Evaluation of the registered potentials includes shape, latency and amplitude. |
| Measure | Description | Time Frame |
|---|---|---|
| Modification of habituation in percentage, between tests performed before and after DBS | The habituation is the change of amplitude between the first and the second response of the double stimulation during the laser evoked potential. We calculated a percentage | After the second laser evoked potential which occurred around 3 months after STN-DBS |
| Measure | Description | Time Frame |
|---|---|---|
| Change in latency of laser evoked potential responses before and after DBS | latency is calculated in millisecond | After the second laser evoked potential which occurred around 3 months after STN-DBS |
| Change in amplitude of laser evoked potential responses before and after DBS |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stéphane THOBOIS, MD | Hospices Civils de Lyon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Neurologie C, Hôpital Neurologique, HCL | Bron | 69500 | France |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D010146 | Pain |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D066331 | Laser-Evoked Potentials |
| ID | Term |
|---|---|
| D005073 | Evoked Potentials, Somatosensory |
| D005071 | Evoked Potentials |
| D000071080 | Cortical Excitability |
| D055724 | Electrophysiological Phenomena |
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|
amplitude is calculated in microvolts |
| After the second laser evoked potential which occurred around 3 months after STN-DBS |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010829 | Physiological Phenomena |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |