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This study will prove to concept of effectiveness of NHF in combination with a nebulizer on reversibility of lung function in COPD patients.
Patients will inhale on day 1 with a nebulizer and on another day with combination of nebulizer an NHF in a randomised order.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| inhalation with nebulizer | Placebo Comparator | inhalation with an nebulizer via mouth |
|
| inhalation with nebulizer and NHF | Active Comparator | inhalation with combination of nebulizer and nasal high flow (NHF) via nasal cavity |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nasal high flow (NHF) | Device | NHF will be combinated with a nebulizer. Inhalation will be done on nasal cavity. |
|
| Measure | Description | Time Frame |
|---|---|---|
| changes in forced expiratory volume in 1s (FEV1) | litre | 45 minutes |
| changes in breath way resistance (Rtot) | 45 min |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hubert Wirtz, MD | University of Leipzig | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Respiratory Medicine | Leipzig | Saxony | 04103 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29261402 | Derived | Braunlich J, Wirtz H. Oral Versus Nasal High-Flow Bronchodilator Inhalation in Chronic Obstructive Pulmonary Disease. J Aerosol Med Pulm Drug Deliv. 2018 Aug;31(4):248-254. doi: 10.1089/jamp.2017.1432. Epub 2017 Dec 20. |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| ID | Term |
|---|---|
| D009330 | Nebulizers and Vaporizers |
| ID | Term |
|---|---|
| D004864 | Equipment and Supplies |
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| Nebulizer | Device | Inhalation will be done will Nebulizer and via mouth |
|
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |