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| Name | Class |
|---|---|
| National Cancer Institute, France | OTHER_GOV |
| Oncogeriatric Coordination Unit (UCOG) - Sud-Val-de-Marne | UNKNOWN |
| Oncogeriatric Coordination Unit (UCOG) - Paris-Ouest | UNKNOWN |
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The management of older patients with cancer has become a major public health concern in Western countries because of the aging of the population and steady increase in cancer incidence with advancing age. Cancer treatment of aged patients is complex due to comorbidities, polypharmacy and functional status. The heterogeneity of the older population in terms of comorbidities and functional status may explain the difficulty in establishing management recommendations.
Study hypothesis is that a geriatric consultation using Geriatric Assessment (GA) can evaluate patient's resource and strengths, in order to help oncologist to define the most effective treatment. The GA developed by geriatricians and recommended by the International Society of Geriatric Oncology (SIOG), is a multidimensional assessment of general health status; comorbidities; functional status; nutritional, cognitive, psychological, and social parameters; and medications. The GA uses validated geriatric scales to produce an inventory of problems, which can then serve to develop an individualized geriatric intervention plan; it may be an important step in selecting elderly patients for cancer screening and treatment.
The objectives are:
Method: The ELCAPA (ELderly CAncer PAtient) survey is a French multicentric prospective study that includes all patients age 70 years or older who has a diagnosis of solid cancer or hematologic malignancies in French hospitals
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Elderly cancer patient cohort | Patients aged 70 years or older, who had diagnosis of cancer in participating sites (including hematologic malignancies), and referred to a geriatrician for geriatric assessment (GA) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Extensive GA | Other | GA includes an evaluation of nine domains according to international recommendations :
|
| Measure | Description | Time Frame |
|---|---|---|
| Difference between initial oncologist treatment proposal and final treatment selected after geriatric assessment | through multidisciplinary meeting decision, an average of 2 weeks after GA (+/-1 week). |
| Measure | Description | Time Frame |
|---|---|---|
| Chemotherapy toxicities using Common Terminology Criteria for Adverse Events | through chemotherapy treatment completion, an average of 6-months after inclusion (+/- 3 months) (according to curative or palliative and chemotherapy protocols). | |
| Feasibility of the planned Chemotherapy treatment (delivery of the planned number of cycles determined based on tumor site and metastatic status) |
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Inclusion Criteria:
Exclusion Criteria:
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All patients aged 70 years or older, who had diagnosis of cancer (including hematologic malignancies), and referred to a getrician for GA in participating sites
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| PHILIPPE CAILLET, MD | Contact | (0)149814707 | +33 | philippe.caillet@aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| PHILIPPE CAILLET, MD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| ELENA PAILLAUD, MD-PhD | Assistance Publique - Hôpitaux de Paris | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Henri Mondor Hospital | Recruiting | Créteil | 94010 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36306481 | Derived | Gonzalez Serrano A, Laurent M, Barnay T, Martinez-Tapia C, Audureau E, Boudou-Rouquette P, Aparicio T, Rollot-Trad F, Soubeyran P, Bellera C, Caillet P, Paillaud E, Canoui-Poitrine F. A Two-Step Frailty Assessment Strategy in Older Patients With Solid Tumors: A Decision Curve Analysis. J Clin Oncol. 2023 Feb 1;41(4):826-834. doi: 10.1200/JCO.22.01118. Epub 2022 Oct 28. | |
| 32889525 |
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| ID | Term |
|---|---|
| D019337 | Hematologic Neoplasms |
| D009369 | Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| Cancéropôle Ile De France |
| OTHER |
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|
| through chemotherapy treatment completion, an average of 6-months after inclusion (+/- 3 months) (according to curative ou palliative and chemotherapy protocols). |
| Overall mortality | Year 1 and 5 years follow-up |
| FLORENCE CANOUI-POITRINE, MD-PhD |
| Assistance Publique - Hôpitaux de Paris |
| Study Director |
| Derived |
| Martinez-Tapia C, Diot T, Oubaya N, Paillaud E, Poisson J, Gisselbrecht M, Morisset L, Caillet P, Baudin A, Pamoukdjian F, Broussier A, Bastuji-Garin S, Laurent M, Canoui-Poitrine F. The obesity paradox for mid- and long-term mortality in older cancer patients: a prospective multicenter cohort study. Am J Clin Nutr. 2021 Jan;113(1):129-141. doi: 10.1093/ajcn/nqaa238. Epub 2020 Sep 5. |