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| Name | Class |
|---|---|
| Ibn Sina Hospital | OTHER_GOV |
| Sadat City University | OTHER |
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In the way for developing and optimizing protocol to be used as non- invasive methodology used as routine testing for PGS.
This protocol is to be adapted to replace the using of life embryo cells for genetic testing and aneuploidy study as well as for any type of genetic testing including single gene disorder or HLA typing or study.
Compare 100 embryos studied using NGS for chromosomal aneuploidies, and compare the results came from free media DNA with this results.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NGS reading for Media Free DNA | Ability to read the DNA product available in embryo culture media using NGS to have valuable diagnostic image for genetic composition of embryo before implantation. |
| |
| NGS reading for blastomer DNA | DNA extracted from Blastomere used for aneuploidy screening. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NGS reading for Media Free DNA | Procedure | NGS reading for Media Free DNA instead of blstomer biopsy |
|
| Measure | Description | Time Frame |
|---|---|---|
| DNA isolation | reading amplified DNA using NGS | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| NGS evaluation | Free DNA isolation and amplification using WGA | 2 years |
| Comparison with cell reading using NGS | compare the obtained result with the results provided collected for the same embryo using its blastomer for PGS |
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Inclusion Criteria:
Exclusion Criteria:
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Embryos arranged for PGS study
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| Name | Affiliation | Role |
|---|---|---|
| Omima Khamis, PHD | Genetic Engineering Institute | Study Director |
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To publish it when it is completed.
once final results released.
01-December 2019
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| ID | Term |
|---|---|
| D002869 | Chromosome Aberrations |
| D030342 | Genetic Diseases, Inborn |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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Blastomer for growing IVF embryos culture media with its free DNA
| 2 years |