Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock

Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock

Retrospective study to examine the effects of chronic antihypertensive medications on vasopressor dosing in septic shock

This will be a retrospective four-cohort study. The four cohorts will be septic shock patients that were: 1) not on either a chronic β-blocker or chronic angiotensin-converting-enzyme inhibitor (ACE-Inhibitor), 2) on chronic β-blocker, 3) on ACE-Inhibitor, and 4) on both chronic β-blocker and ACE-inhibitor

Inclusion Criteria:

• Adult patients 18 years of age or older
• Diagnosis of septic shock requiring vasopressor therapy (norepinephrine, epinephrine, phenylephrine, dopamine, or vasopressin)
• Admitted to an intensive care unit (ICU) at Rush University Medical Center (RUMC)
• Time frame: 01/01/2012 to 07/1/2016

Exclusion Criteria:

• Pregnant patients
• Transfer from outside hospital on vasopressors
• Admitted in cardiopulmonary arrest
• Prior arrest within 24 hours of admission to RUMC