We aim to evaluate the long-term effects of 10 sessions of spinal manipulative therapy applied in a vertebral region-specific or region nonspecific level immediately after treatment and 3 and 6 months after randomization.

To evaluate the long-term effects of 10 sessions of spinal manipulative therapy applied in a vertebral region-specific or region nonspecific level immediately after treatment and 3 and 6 months after randomization.

148 patients with chronic non-specific low back pain will be enrolled for this clinical trial. Patients will undergo to a specific physical examination in order to determine the ideal lumbar spine level to be manipulated. The outcomes of interest are pain intensity, pain pressure threshold, global perceived effect and disability associated with back pain. After the first assessment patients will be randomly assigned to two groups that will receive 10 sessions of spinal manipulation over a period of four weeks, and may receive manipulation according to the findings on physical examination (specific manipulation) or may receive manipulation in the upper thoracic region, disregarding the physical examination findings (nonspecific manipulation).

Inclusion Criteria:

- Patients with low back pain duration from 3 to 24 months.

Exclusion criteria:

• Patients with a pain duration lower than 3 months and higher than 24 months.
• Patients with nerve root compromise or with serious spinal pathology,
• Pregnant patients,
• Previous back surgery
• Patients with any contra-indication to spinal manipulation.

We are happy to share our data with researchers that would like to use it on an IPD.