Analysis of Immune Response In Bacterial Infection of Obese Subject

Analysis of Immune Response In Bacterial Infection of Obese Subject

Improve knowledge of the immune response to sepsis in obese patients. Define immunological and genetic prognostic factors of severe infections which can motivate a change in the therapeutic attitude

Inclusion Criteria:

• between18 and 80 years

• obesity: BMI > 30

• presumed bacterial infection:

  • pneumonitis (documented or probably)
  • pyelonephritis / acute prostatitis
  • soft tissue / skin infection (except for bedsore)
  • cholecystitis / angiocholitis
  • meningitis
  • clostridium colitis
  • surgical site infection

• signed consent

Exclusion Criteria:

• patients with viral, parasitic or mycotic documented infection
• patients with bacterial infection with treatment> 4 weeks (ex. endocarditis; osteo- articular infections)
• patients with prior antibiotic treatment (< 14 days)
• intensive care unit patients
• patients with a history of cancer or malignant hematological disease within the 5 previous years that is currently clinically significant (non metastatic prostatic and basocellular malignancy are excluded)
• patients with systemic disease
• Known diagnosis of human immunodeficiency infection (DICV, HIV…)
• immunosuppression treatment during last month including corticotherapy
• pregnancy
• 3 months follow up not possible
• non signed consent