Pinaverium bromide can be used to treat symptoms related to irritable bowel syndrome (IBS) and functional disorders of the biliary tract. In this study, pinaverium bromide was compared with Vitamin C for the facilitation of bile duct and pancreatic duct cannulation in patients. The primary outcome was successful deep bile duct cannulation and pancreatic duct canulation. The second outcome was the major papillary orifice,bile juice flow from the papilla, time to achieve deep bile duct cannulation, fluoroscopy time for deep bile duct cannulation,the appearance of the major and minor papillary orifice, pancreatic juice flow from the papilla, time to achieve deep pancreatic duct cannulation, and fluoroscopy time for deep pancreatic duct cannulation in the pinaverium bromide group versus Vitamin C group.

Inclusion Criteria:

1. those with intact native papilla,
2. who underwent endoscopic retrograde choledochopancreatography for bile duct,
3. age≥18 years, ≤80years, and
4. agreement to participate in the study.

Exclusion Criteria:

1. a previous sphincterotomy,
2. previous attempted or unsuccessful endoscopic retrograde choledochopancreatography with papillary manipulation,
3. indwelling biliary or pancreatic stent(s),
4. active acute pancreatitis,
5. active acute pancreatitis
6. altered/postsurgical anatomy,
7. history of gastroparesis,
8. endoscopic retrograde choledochopancreatography for sphincter of Oddi's sphincter(SO) manometry,
9. known tumor of the major duodenal papilla, and
10. patients with any medication probably affecting SO motility