nTMS for Motor Mapping of Rolandic Lesions

Randomized Controlled Multicenter Trial on the Impact of Presurgical Navigated Transcranial Magnetic Stimulation for Motor Mapping of Rolandic Lesions

To compare presurgical motor mapping by navigated transcranial magnetic stimulation for surgery (nTMS) of rolandic lesions to surgery with mapping without implementing these data into neuronavigation as control.

Primary objective: Permanently new postoperative deficit is lower when the preoperative motor mapping is available to the surgeon

Experimental intervention:

presurgical motor mapping by navigated transcranial magnetic stimulation and fusion with intraoperative neuronavigation

Control intervention:

presurgical motor mapping by navigated transcranial magnetic stimulation without access of the surgeon to this data Follow-up per patient: 6 months Duration of intervention per patient: 45 minutes

Key inclusion criteria:

• indication for resection of a supratentorial tumor within or adjacent to the primary motor cortex
• preoperative nTMS mapping of the ipsilateral hemisphere
• implementation of the mapping data into preoperative planning
• continuous MEP monitoring - informed consent

Key exclusion criteria:

• no motor eloquent tumor
• infratentorial tumor
• no postoperative imaging
• prognosis lower than 3 months of survival - age <18 years