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Phase II study of radiochemotherapy for elderly patients with oesophagus cancer.
Phase II study of radiochemotherapy for elderly patients with oesophagus cancer with Radiotherapy = 50 Gy, 2Gy/f ans chemotherapy with 2 arms arm Cisplatin = Cisplatin 75mg/m2 J1J22 or arm Oxaliplatine = oxaliplatine 85mg/m2 every 2 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm Cisplatin | Active Comparator | Radiotherapy 50 Gy with cisplatin 75 mg/2 Day 1 and day 22 (2) |
|
| Arm Oxaliplatin | Experimental | Radiotherapy 50Gy Oxaliplatin 85mg/m2 every 2 weeks, (6) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cisplatin | Drug | Arm cisplatin : 75mg/m2, day n*1 and day n*22, And radiotherapy 50 Gy, 2Gy/f |
|
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of treatment: Number of patients with completed treatment | number of patient with completed treatment | 6 weeks after end of the radiochemotherapy |
| Measure | Description | Time Frame |
|---|---|---|
| Tumoral response | tumoral evaluation at 6 weeks after the treatment | 6 weeks after end of the radiochemotherapy |
| Quality of life | QLQC30 |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19358620 | Background | Servagi-Vernat S, Bosset M, Crehange G, Buffet-Miny J, Puyraveau M, Maingon P, Mercier M, Bosset JF. Feasibility of chemoradiotherapy for oesophageal cancer in elderly patients aged >or=75 years: a prospective, single-arm phase II study. Drugs Aging. 2009;26(3):255-62. doi: 10.2165/00002512-200926030-00006. | |
| 26038198 | Result |
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| ID | Term |
|---|---|
| D004938 | Esophageal Neoplasms |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D002945 | Cisplatin |
| D000077150 | Oxaliplatin |
| ID | Term |
|---|---|
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
| D017671 | Platinum Compounds |
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| Oxaliplatin | Drug | 85 mg/m2 every 2 weeks, 6 times And radiotherapy 50 Gy, 2Gy/f |
|
|
| 6 weeks after end of the radiochemotherapy |
| Quality of life | ELD14 | 6 weeks after end of the radiochemotherapy |
| Servagi-Vernat S, Crehange G, Roullet B, Guimas V, Maingon P, Puyraveau M, Bosset JF. Phase II Study of a Platinum-Based Adapted Chemotherapy Regimen Combined with Radiotherapy in Patients 75 Years and Older with Esophageal Cancer. Drugs Aging. 2015 Jun;32(6):487-93. doi: 10.1007/s40266-015-0275-8. |
| D006258 |
| Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D056831 |
| Coordination Complexes |
| D009930 | Organic Chemicals |