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| ID | Type | Description | Link |
|---|---|---|---|
| Vajira002 | Registry Identifier | SLED |
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The investigators conducted a comparison trial between SLED and CRRT in critically ill patients to evaluate the outcome for all cause mortality at 30 day . The secondary outcome were recovery of renal function, complications during therapy and duration of hospitalization.
The investigators performed a single center experience accumulated over 12 months since February 2009 with a continuous venovenous hemodiafiltration (CVVHDF) and hybrid technique named sustained low-efficiency dialysis (SLED). The primary end point was death from any cause by day 30. Intensive care unit (ICU) patients were eligible for inclusion when serum creatinine was > 2 mg/dL, and renal replacement therapy (RRT) was initiated. The selected patients were treated with CVVHDF or SLED.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Slow efficiency dialysis | Active Comparator | SLED is a kind of hemodialysis technique performed using Fresenius 4008B dialysis machine with FDX 120 GW (NIKKISO Japan) dialyzer. SLED sessions were 6-8 hour duration, three times per week (except Sunday), In case of severe volume overload, the session could be increased to meet clinical situation. Blood flow was maintained between 150-200 mL/hr and the dialysate flow of 300 mL/hr. Both the groups use unfractionated heparin as anticoagulant to prevent clotting of the extracorporeal circuit .the target partial thromboplastin time( PTT) was not more than twice the control level. |
|
| Continuous renal replacement therapy | No Intervention | CRRT is a kind of therapy involved continuos dialysis throughout 24 hours by using Edward Delivery system (Edward Life Science) as continuous venovenous hemodiafiltration (CVVHDF) mode using Aquamax HF 12 dialyzer. Blood flow rate was kept from 100-200 mL/hr and target effluent rates of 20 mL/hr . The substitution fluid was infused at a rate of 1,000 ml/hr with ultrafiltration rate at 100-300 mL/hr.Intervention here is the different mode of dialysis |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Slow efficiency dialysis | Procedure | Slow dialysis 4 times weekly 8 hours CVVHDF predilution mode |
|
| Measure | Description | Time Frame |
|---|---|---|
| All-cause mortality | ll-cause mortality at 30 days following RRT initiation | 30 day |
| Measure | Description | Time Frame |
|---|---|---|
| Numbers of patients with abnormal laboratory values | Renal function impairment | 30 days |
| ICU stay | Total days in ICU | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse events during treatment | Number of patients with catheter infection | 30 days |
Inclusion Criteria:
- The inclusion criteria were
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Renal Unit, BMA Medical College and Vajira Hospital | Bangkok | 10300 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12576950 | Result | Manns B, Doig CJ, Lee H, Dean S, Tonelli M, Johnson D, Donaldson C. Cost of acute renal failure requiring dialysis in the intensive care unit: clinical and resource implications of renal recovery. Crit Care Med. 2003 Feb;31(2):449-55. doi: 10.1097/01.CCM.0000045182.90302.B3. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
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