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In order to identify the responding patients with vascular filling test, this research aims to compare the performance of the increased flow in the femoral artery to the performance of the blood pressure increase.
The reference measurement will increase cardiac output measured by ultrasound.
It is notable that in the intensive care patient, the ultrasound measurement of cardiac flow is not always possible, especially in case of mechanical ventilation, often responsible for air interposed between the ultrasound probe and the heart, thus stopping the ultrasound. Use the blood pressure increase as a reflection of the increase in cardiac flow induced by fluid replacement is not a fully satisfactory alternative since its performance is at best just acceptable.
Flow measurement in the femoral artery could be an attractive alternative to the cardiac output measurement as:
Pathophysiology study, multicenter (conducted in three French ICUs), open, prospective in order to evaluate the flow doppler from the femoral artery as a reflection of cardiac flow in a vascular fluid test in patient with signs of acute circulatory failure in intensive care unit.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Doppler measurement of blood flow in the outflow tract of the left ventricle and the femoral artery,Reading blood pressures displayed on the monitor. | Procedure |
| Measure | Description | Time Frame |
|---|---|---|
| In the intensive care patient of acute circulatory failure signs, assess the increase of the femoral arterial flow (specifically its full-time speed, ΔRVAFitv measured by Doppler ultrasound) to identify responders this fluid replacement. | First patient enrollment: april 2014 - Study duration: 24 month - Patient follow-up: 30 minutes |
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Inclusion Criteria:
Patient hospitalized in intensive care and affiliated to a social security system
Intra-arterial catheter already in place and operational
Stability blood pressure for 5 min (no change in mean arterial pressure> 10%, no increase in dose catecholamine)
Presence of at least one sign of acute circulatory failure from:
The doctor in charge has prescribed a fluid loading test, regardless of the needs of the study.
Non inclusion criteria:
Clear contraindication to the femoral artery Doppler (wound or burn the groin, for example)
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One hundred and twenty adult patients hospitalized in one of the participating ICUs, will be included (see the justification required number of subjects in "statistics") if
They are already carrying an intra-arterial catheter (femoral or radial).
They exhibit acute circulatory failure signs (see below)
The doctor in charge prescribed a vascular fluid replacement, regardless of the purposes of the study:
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Karim LAKHAL, Dr | Contact | lakhal_karim@yahoo.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nantes | Recruiting | Nantes | 44000 | France |
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| ID | Term |
|---|---|
| D012769 | Shock |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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