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| Name | Class |
|---|---|
| Kwame Nkrumah University of Science and Technology | OTHER |
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The aim of this study was to determine the effect of combining vitamin A (VA), zinc (Z) and multivitamins (MV- A, B1, B2, B6, B12, C, D and E) on malaria morbidity
A total of 542 children aged between 6-59 months received either: (i) VA (control) or (ii) VA & Z (VAZ) or (iii) VA, Z & MV (VAZM). VA was delivered as a single dose while MV and Z were delivered daily. Malaria cases were managed by community health workers, who used rapid diagnostic test to confirm infection prior to treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vitamin A | Placebo Comparator | A single dose of 20,000IU Vitamin A for the whole study period |
|
| Vitamin A and zinc | Active Comparator | A single dose of 20,000IU Vitamin A and 10mg of elemental zinc each day for 5 months |
|
| Vitamin A , Zinc and Multivitamin | Active Comparator | A single dose of 20,000IU Vitamin A , 10mg of elemental zinc each day and 0.5ml/kg multivitamin syrup for 5 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin A | Dietary Supplement | Vitamin A supplements |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of clinical malaria attacks | While taking the supplement, malaria incidence will be measured | Baseline and every month up to six months |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of diarrhea attacks | While taking the supplement, diarrhea incidence will be measured | Every month up to six months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Patricia k Brown, PhD | Kwame Nkrumah Univeristy of Science and Technolgy | Study Chair |
| Wilhelmina A Mensah, Mphil | University of Ghana | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Amoako | Accra | Accra | 233 | Ghana |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22131908 | Background | Veenemans J, Milligan P, Prentice AM, Schouten LR, Inja N, van der Heijden AC, de Boer LC, Jansen EJ, Koopmans AE, Enthoven WT, Kraaijenhagen RJ, Demir AY, Uges DR, Mbugi EV, Savelkoul HF, Verhoef H. Effect of supplementation with zinc and other micronutrients on malaria in Tanzanian children: a randomised trial. PLoS Med. 2011 Nov;8(11):e1001125. doi: 10.1371/journal.pmed.1001125. Epub 2011 Nov 22. | |
| 18237394 |
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To meet the participants and explain the results of their data to them
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| ID | Term |
|---|---|
| D008288 | Malaria |
| ID | Term |
|---|---|
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
| D000096724 | Mosquito-Borne Diseases |
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| ID | Term |
|---|---|
| D014801 | Vitamin A |
| D015032 | Zinc |
| C067316 | Geritol |
| ID | Term |
|---|---|
| D012176 | Retinoids |
| D002338 | Carotenoids |
| D011090 | Polyenes |
| D000475 | Alkenes |
| D006839 |
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| Vitamin A and ZInc | Dietary Supplement | Combination of vitamin A and zinc supplements |
|
|
| Vitamin A , Zinc and Multivitamin | Dietary Supplement | Combination of vitamin A, zinc and multivitamins |
|
|
| Result |
| Zeba AN, Sorgho H, Rouamba N, Zongo I, Rouamba J, Guiguemde RT, Hamer DH, Mokhtar N, Ouedraogo JB. Major reduction of malaria morbidity with combined vitamin A and zinc supplementation in young children in Burkina Faso: a randomized double blind trial. Nutr J. 2008 Jan 31;7:7. doi: 10.1186/1475-2891-7-7. |
| 24330422 | Result | Owusu-Agyei S, Newton S, Mahama E, Febir LG, Ali M, Adjei K, Tchum K, Alhassan L, Moleah T, Tanumihardjo SA. Impact of vitamin A with zinc supplementation on malaria morbidity in Ghana. Nutr J. 2013 Sep 23;12:131. doi: 10.1186/1475-2891-12-131. |
| 21154399 | Result | Imdad A, Herzer K, Mayo-Wilson E, Yakoob MY, Bhutta ZA. Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD008524. doi: 10.1002/14651858.CD008524.pub2. |
| D000079426 |
| Vector Borne Diseases |
| Hydrocarbons, Acyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D053138 | Cyclohexenes |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D013729 | Terpenes |
| D004224 | Diterpenes |
| D010860 | Pigments, Biological |
| D001685 | Biological Factors |
| D019216 | Metals, Heavy |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D028561 | Transition Elements |
| D008670 | Metals |