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CARMEN is a national, real-world clinical registry of all adult patients with incident diagnosis of Immune thrombocytopenia (ITP) or Autoimmune Hemolytic anemia (AIHA) patients in France. It is aimed at describing ITP and AIHA clinical features, assessing the real-world risk-benefit ratio of treatments and adherence to guidelines for ITP and AIHA management.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no specific intervention | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Immune thrombocytopenia (ITP) and AIHA | Number of new cases | Baseline |
| Natural evolution and events | Disease duration. Description of bleeding, infection, thrombosis events | Baseline and follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Response | platelet count >30 G/L and no bleeding | 15 years |
| Complete rate | platelet count >30 G/L and no bleeding | 15 years |
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Inclusion Criteria:
Exclusion criteria:
- opposition to data collection
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Multicentric adult ITP and AIHA case recording in France, selected in centers of the French Referral Autoimmune Cytopenia Network. Both secondary and tertiary (referral) centers are participating (N=44).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Moulis Guillaume, MD PhD | Contact | moulis.g@chu-toulouse.fr | ||
| Johanne Germain, PhD | Contact | johanne.germain@inserm.fr |
| Name | Affiliation | Role |
|---|---|---|
| Moulis Guillaume, MD PhD | University Hopsital Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Médecine Interne | Recruiting | Toulouse | 31000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39874521 | Derived | Larue M, Moulis G, Rueter M, Audia S, Comont T, Terriou L, Viallard JF, Pan-Petesch B, Royer B, Bonnotte B, Galicier L, Lambotte O, Lefrere F, Cheze S, Ebbo M, Duong TA, Boutin E, Languille L, Mahevas M, Godeau B, Canoui-Poitrine F, Michel M. Efficacy and safety of dapsone in adult primary immune thrombocytopenia. Blood Adv. 2025 Apr 22;9(8):1976-1983. doi: 10.1182/bloodadvances.2024014939. |
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| ID | Term |
|---|---|
| D016553 | Purpura, Thrombocytopenic, Idiopathic |
| D000744 | Anemia, Hemolytic, Autoimmune |
| ID | Term |
|---|---|
| D011696 | Purpura, Thrombocytopenic |
| D011693 | Purpura |
| D001778 | Blood Coagulation Disorders |
| D006402 | Hematologic Diseases |
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| Treatment lines | % of patients with each treatment by line of treatments | 15 years |
| Adverse drug reactions | % of patients with adverse drug reaction reported by investigators | 15 years |
| Bleeding | % of patients with bleeding during follow-up | 15 years |
| Rescue treatment | % of patients with any treatment added during the exposure of ongoing treatment | 15 years |
| Adherence to ITP management guidelines. | Percentage of patients who benefitted from the recommended examinations to detect secondary ITP and the percentage of patients who benefitted from the recommended first-line and second line treatments | 15 years |
| Events | % of patients with other events of interest like cancer, death, infection, thrombosis | 15 years |
| D006425 |
| Hemic and Lymphatic Diseases |
| D057049 | Thrombotic Microangiopathies |
| D013921 | Thrombocytopenia |
| D001791 | Blood Platelet Disorders |
| D000095542 | Cytopenia |
| D006474 | Hemorrhagic Disorders |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012877 | Skin Manifestations |
| D012816 | Signs and Symptoms |
| D000743 | Anemia, Hemolytic |
| D000740 | Anemia |