Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND) | NCT02876835 | Trialant

Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND) | NCT02876835 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Age: 18 to 99 years of age (inclusive)

CKD stage: Kidney Disease Outcomes Quality Initiative (KDOQI) CKD stages 3, 4, or 5 defined by electronic eGFR using the CKD Epidemiology Collaboration (CKD-EPI) formula.

Erythropoietin-stimulating agents (ESAs)/Hgb: Group 1 (not using ESAs): No ESA use within the 6 weeks prior to screening and no ESA use between screening and randomization (Day 1). Group 2 (ESA users): Use of any approved ESA for the 6 weeks prior to screening and continuing between screening and randomization.

For Group 1 (not using ESAs), Hgb concentration at Week -8 and Week 1 should be 8 to 10 gram per deciliter (g/dL). For Group 2 (ESA users), Hgb concentration at Week -8 should be 8 to 12 g/dL and at Week 1 should be 8 to 11 g/dL.

>=80% and <=120% compliance with placebo during run-in period.

Informed consent (screening only): capable of giving signed informed consent which includes compliance with the requirements and restrictions.

Exclusion Criteria:

Dialysis: On dialysis or clinical evidence of impending need to initiate dialysis within 90 days after study start (Day 1).

Kidney transplant: Planned living-related or living-unrelated kidney transplant within 52 weeks after study start (Day 1).

Ferritin: <=100 nanograms (ng)/milliliter (mL) (<=100 micrograms/liter [L]) at screening.

Transferrin saturation (TSAT) (screening only): <=20%.

Aplasias: History of bone marrow aplasia or pure red cell aplasia.

Other causes of anemia: untreated pernicious anemia, thalassemia major, sickle cell disease or myelodysplastic syndrome.

Gastrointestinal (GI) bleeding: Evidence of actively bleeding gastric, duodenal, or esophageal ulcer disease or clinically significant GI bleeding <=4 weeks prior to screening through to randomization (Day 1).

MI or acute coronary syndrome: <=4 weeks prior to screening through to randomization (Day 1).

Stroke or transient ischemic attack: <=4 weeks prior to screening through to randomization (Day 1).

Heart failure (HF): Chronic Class IV HF, as defined by the New York Heart Association (NYHA) functional classification system.

Current uncontrolled hypertension: Current uncontrolled hypertension as determined by the investigator.

Bazett's corrected QT interval (QTcB) (Day 1): QTcB >500 millisecond (msec), or QTcB >530 msec in subjects with bundle branch block. There is no Q-T Interval Corrected for Heart Rate (QTc) exclusion for subjects with a predominantly ventricular paced rhythm.

Alanine transaminase (ALT): >2x upper limit of normal (ULN) at screening.

Bilirubin: >1.5xULN at screening.

Current unstable liver or biliary disease per investigator assessment, generally defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminaemia, esophageal or gastric varices, persistent jaundice, or cirrhosis.

Malignancy: History of malignancy within the 2 years prior to screening through to randomization (Day 1) or currently receiving treatment for cancer, or complex kidney cyst (example [e.g.] Bosniak Category II F, III or IV) > 3 centimeter (cm); with the exception of localized squamous cell or basal cell carcinoma of the skin that has been definitively treated >=4 weeks prior to screening.

Severe allergic reactions: History of severe allergic or anaphylactic reactions or hypersensitivity to excipients in the investigational product, or darbepoetin alfa.

Drugs and supplements: Use of strong inhibitors of Cytochrome P4502C8 (CYP2C8) (e.g., gemfibrozil) or strong inducers of CYP2C8 (e.g., rifampin/rifampicin).

Other study participation: Use of other investigational agent or device prior to screening through to randomization (Day 1). At screening, this exclusion applies to use of the investigational agent within 30 days or within five half lives (whichever is longer).

Prior treatment with daprodustat: Any prior treatment with daprodustat for treatment duration of >30 days.

Females only: Subject is pregnant [as confirmed by a positive urine human chorionic gonadotrophin (hCG) test for females of reproductive potential (FRP) only], subject is breastfeeding, or subject is of reproductive potential and does not agree to follow one of the contraceptive options.

Other Conditions: Any other condition, clinical or laboratory abnormality, or examination finding that the investigator considers would put the subject at unacceptable risk, which may affect study compliance (e.g., intolerance to darbepoetin alfa) or prevent understanding of the aims or investigational procedures or possible consequences of the study.

GSK Investigational Site

Andalusia, Alabama 36420, United States

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Birmingham, Alabama 35249, United States

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Huntsville, Alabama 35805, United States

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Glendale, Arizona 85305, United States

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Mesa, Arizona 85202, United States

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Phoenix, Arizona 85016, United States

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Phoenix, Arizona 85027, United States

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Scottsdale, Arizona 48201, United States

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Tucson, Arizona 85745, United States

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Azusa, California 91702, United States

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Bakersfield, California 93308, United States

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Bakersfield, California 93309, United States

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Chula Vista, California 91910, United States

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Cudahy, California 90201, United States

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El Centro, California 92243, United States

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Escondido, California 92025, United States

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Glendale, California 91204, United States

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Granada Hills, California 91344, United States

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Long Beach, California 90806, United States

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Los Angeles, California 90022, United States

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Montebello, California 90640, United States

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National City, California 91950, United States

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Simi Valley, California 93065, United States

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Tarzana, California 91356, United States

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Whittier, California 90602, United States

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Middlebury, Connecticut 06762, United States

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Washington D.C., District of Columbia 20037, United States

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Aventura, Florida 33180, United States

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Boca Raton, Florida 33431, United States

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Coral Gables, Florida 33134, United States

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Cutler Bay, Florida 33189, United States

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Doral, Florida 33122, United States

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Fort Lauderdale, Florida 33308, United States

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Homestead, Florida 33033, United States

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Hudson, Florida 34667, United States

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Jacksonville, Florida 32224, United States

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Jacksonville, Florida 32256, United States

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Lauderdale Lakes, Florida 33313, United States

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Miami, Florida 33126, United States

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Miami, Florida 33143, United States

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Miami, Florida 33145, United States

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Miami, Florida 33147, United States

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Miami, Florida 33150, United States

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Miami, Florida 33155, United States

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Miami, Florida 33156, United States

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Miami, Florida 33165, United States

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Miami, Florida 33169, United States

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Miami, Florida 33173, United States

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Miami Gardens, Florida 33169, United States

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Miami Lakes, Florida 33014, United States

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Ocala, Florida 34471, United States

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Orlando, Florida 32810, United States

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Pembroke Pines, Florida 33028, United States

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Port Charlotte, Florida 33952, United States

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South Miami, Florida 33143, United States

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Tampa, Florida 33612, United States

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Temple Terrace, Florida 33637, United States

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Atlanta, Georgia 30342, United States

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Augusta, Georgia 30904, United States

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Augusta, Georgia 30909, United States

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Augusta, Georgia 30912, United States

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Columbus, Georgia 31904, United States

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Nampa, Idaho 83687, United States

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Chicago, Illinois 60611, United States

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Takoma Park, Maryland 20912-6385, United States

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Boston, Massachusetts 02114, United States

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Detroit, Michigan 48202, United States

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Kalamazoo, Michigan 49007, United States

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Pontiac, Michigan 48341, United States

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Minneapolis, Minnesota 55414, United States

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Jackson, Mississippi 39216, United States

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Tupelo, Mississippi 38801, United States

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St Louis, Missouri 63106, United States

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St Louis, Missouri 63110, United States

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North Platte, Nebraska 69101, United States

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Las Vegas, Nevada 89106, United States

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Brooklyn, New York 11203, United States

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Laurelton, New York 11413, United States

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New York, New York 10021, United States

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New York, New York 10029, United States

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Ridgewood, New York 11385, United States

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The Bronx, New York 10461, United States

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The Bronx, New York 10467, United States

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Yonkers, New York 10704, United States

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Charlotte, North Carolina 28204, United States

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Raleigh, North Carolina 27609, United States

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Rocky Mount, North Carolina 27804, United States

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Wilmington, North Carolina 28401, United States

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Winston-Salem, North Carolina 27103, United States

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Grand Forks, North Dakota 58201, United States

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Canton, Ohio 15212, United States

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Cincinnati, Ohio 45206, United States

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Cincinnati, Ohio 45220, United States

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Mentor, Ohio 44060, United States

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Lawton, Oklahoma 73505, United States

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Portland, Oregon 97210, United States

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Roseburg, Oregon 97471, United States

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Bethlehem, Pennsylvania 18017, United States

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Doylestown, Pennsylvania 18901, United States

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Lancaster, Pennsylvania 17601, United States

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Upland, Pennsylvania 19013, United States

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Wyomissing, Pennsylvania 19610, United States

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Anderson, South Carolina 29621, United States

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Charleston, South Carolina 29425, United States

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Columbia, South Carolina 29209, United States

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Sumter, South Carolina 29150, United States

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Cordova, Tennessee 38018, United States

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Knoxville, Tennessee 37923, United States

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Memphis, Tennessee 38163, United States

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Nashville, Tennessee 37205, United States

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Arlington, Texas 76002, United States

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Austin, Texas 78751, United States

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Austin, Texas 78758, United States

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Corpus Christi, Texas 78404, United States

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Corsicana, Texas 75110, United States

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Dallas, Texas 75237, United States

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Dallas, Texas 75246, United States

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Houston, Texas 77004, United States

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Houston, Texas 77043, United States

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Houston, Texas 77084, United States

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Houston, Texas 77099, United States

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Lufkin, Texas 75904, United States

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McAllen, Texas 78503, United States

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Fairfax, Virginia 22033, United States

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Hampton, Virginia 23666, United States

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Coronel Suárez, Buenos Aires 7540, Argentina

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Mar del Plata, Buenos Aires 7600, Argentina

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Córdoba, Córdoba Province 5000, Argentina

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Córdoba, Córdoba Province X5016KEH, Argentina

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Buenos Aires, 1425, Argentina

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Mendoza, M5500AFA, Argentina

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Morón, B1708DPO, Argentina

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San Miguel de Tucumán, T4000AHL, Argentina

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Garran, Australian Capital Territory 2606, Australia

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Kingswood, New South Wales 2747, Australia

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Kogarah, New South Wales 2217, Australia

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St Leonards, New South Wales 2065, Australia

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Wollongong, New South Wales 2500, Australia

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Nambour, Queensland 4560, Australia

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Liège, 4000, Belgium

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Roeselare, 8800, Belgium

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Ronse, 9600, Belgium

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Sint-Niklaas, 9100, Belgium

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Salvador, Estado de Bahia 40415-065, Brazil

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Curitiba, Paraná 80440-020, Brazil

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Curitiba, Paraná 80730-150, Brazil

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Curitiba, Paraná CEP 80230-130, Brazil

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Passo Fundo, Rio Grande do Sul 99010-080, Brazil

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Porto Alegre, Rio Grande do Sul 90035-074, Brazil

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Porto Alegre, Rio Grande do Sul 90035-903, Brazil

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Porto Alegre, Rio Grande do Sul 90610-000, Brazil

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São José do Rio Preto, São Paulo 15090-000, Brazil

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Votuporanga, São Paulo 15500-003, Brazil

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Belo Horizonte, 30150-320, Brazil

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Brasília, 70840-901, Brazil

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Feira de Santana, 44001-465, Brazil

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Joinville, 89201-010, Brazil

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Juiz de Fora, 36036-330, Brazil

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São Paulo, 01323903, Brazil

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São Paulo, 04039-000, Brazil

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São Paulo, ?01323-001, Brazil

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São Paulo, ?04005-000, Brazil

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São Paulo, ?08270-070, Brazil

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Blagoevgrad, 2700, Bulgaria

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Burgas, 8000, Bulgaria

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Dobrich, 9300, Bulgaria

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Gabrovo, 5300, Bulgaria

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Lom, 3600, Bulgaria

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Pazardzhik, 4400, Bulgaria

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Plovdiv, 4000, Bulgaria

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Sliven, 8800, Bulgaria

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Smolyan, 4700, Bulgaria

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Sofia, 1233, Bulgaria

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Sofia, 1709, Bulgaria

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Stara Zagora, 6000, Bulgaria

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Varna, 9000, Bulgaria

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Veliko Tarnovo, 5000, Bulgaria

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Edmonton, Alberta T6G 2B7, Canada

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Halifax, Nova Scotia B3H 1V8, Canada

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Brampton, Ontario L6T 0G1, Canada

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London, Ontario N6A 5A5, Canada

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Mississauga, Ontario L4V 1P1, Canada

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Mississauga, Ontario L5M 2V8, Canada

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Toronto, Ontario M4C 5T2, Canada

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Greenfield Park, Quebec J4V 2H1, Canada

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Montreal, Quebec H3G 1A4, Canada

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Québec, Quebec G1R 2J6, Canada

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Barranquilla, 760002, Colombia

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Bogotá, 111711, Colombia

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Cali, 760007, Colombia

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Floridablanca, 681001, Colombia

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Medellín, 050012, Colombia

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Beroun, 26601, Czechia

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Český Krumlov, 38127, Czechia

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Ivančice, 664 95, Czechia

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Jilemnice, 514 01, Czechia

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Mariánské Lázně, 353 01, Czechia

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Nový Jičín, 74101, Czechia

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Pardubice, 53203, Czechia

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Prague, 128 08, Czechia

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Prague, 140 21, Czechia

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Sokolov, 356 01, Czechia

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Aalborg, DK-9000, Denmark

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Holstebro, 7500, Denmark

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Kolding, 6000, Denmark

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Odense C, 5000, Denmark

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Jämejala Village, 71024, Estonia

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Tallinn, EE-13419, Estonia

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Tartu, 50501, Estonia

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Annonay, 07103, France

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Boulogne-Billancourt, 92100, France

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Caen, 14033, France

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Clermont-Ferrand, 63000, France

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Lyon, 69003, France

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Montpellier, 34295, France

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Mulhouse, 68100, France

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Poitiers, 86021, France

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Saint-Ouen, 93400, France

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Mannheim, Baden-Wurttemberg 68167, Germany

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Cloppenburg, Lower Saxony 49661, Germany

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Düsseldorf, North Rhine-Westphalia 40210, Germany

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Münster, North Rhine-Westphalia 48149, Germany

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Kaiserslautern, Rhineland-Palatinate 67655, Germany

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Leipzig, Saxony 04129, Germany

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Wiesbaden, 65191, Germany

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Alexandroupoli, 68100, Greece

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Arta, 471 00, Greece

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Athens, 115 26, Greece

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Athens, 11526, Greece

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Athens, 11527, Greece

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Athens, 12462, Greece

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Efkarpia, 564 29, Greece

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Heraklion-Crete, 71110, Greece

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Ioannina, 45001, Greece

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Ioannina, 45500, Greece

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Komotini, 69100, Greece

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Larissa, 41100, Greece

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Melíssia, 15127, Greece

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Pátrai, 26500, Greece

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Thessaloniki, 546 42, Greece

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Thessaloniki, 54636, Greece

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Thessaloniki, 551 34, Greece

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Thessaloniki, 57001, Greece

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Thessaloniki, 57010, Greece

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Hong Kong, Hong Kong

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Lai Chi Kok, Hong Kong

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New Territories, Hong Kong

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Tsuen Wan, Hong Kong

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Baja, 6500, Hungary

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Balatonfüred, 8230, Hungary

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Esztergom, 2500, Hungary

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Kecskemét, 6000, Hungary

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Miskolc, 3526, Hungary

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Pécs, 7623, Hungary

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Salgótarján, 3100, Hungary

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Szigetvár, 7900, Hungary

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Ahmedabad, 380054, India

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Ahmedabad, 380059, India

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Bangalore, 560054, India

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Bangalore, 560055, India

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Calicut, 673008, India

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Chandigarh, 160012, India

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Chennai, 600037, India

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Chennai, Tamil Nadu, 600 006, India

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Delhi, 110076, India

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Ghaziabad, 201012, India

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Gurgaon, 122001, India

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Hyderabad, 500012, India

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Hyderabad, 500034, India

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Jaipur, 302004, India

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Jaipur, 302018, India

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Lucknow, 226014, India

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Manipal, 576104, India

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Mumbai, 400008, India

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Mumbai, 400016, India

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Nadiād, 387001, India

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Nagpur, 440010, India

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New Delhi, 110002, India

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New Delhi, 110017, India

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New Delhi, 110025, India

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New Delhi, 110060, India

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Pune, 411004, India

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Pune, 411033, India

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Secunderabad, 560020, India

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Trivandrum, 695011, India

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Ashkelon, 78278, Israel

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Hadera, PO Box 169, Israel

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Haifa, 31096, Israel

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Kfar Saba, 44281, Israel

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Nahariya, 22100, Israel

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Nazareth, 16100, Israel

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Poria – Neve Oved, 15208, Israel

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Ẕerifin, 70300, Israel

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Foggia, Apulia 71100, Italy

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Catanzaro, Calabria 88100, Italy

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Naples, Campania 80131, Italy

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Piacenza, Emilia-Romagna 29100, Italy

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Reggio Emilia, Emilia-Romagna 42123, Italy

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Genoa, Liguria 16132, Italy

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Lecco, Lombardy 23900, Italy

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Milan, Lombardy 20132, Italy

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Pavia, Lombardy 27100, Italy

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Turin, Piedmont 10154, Italy

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Cagliari, Sardinia ?09100, Italy

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Imola, 40026, Italy

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Mestre, 30122, Italy

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Alor Star, 55600, Malaysia

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George Town, 10990, Malaysia

GSK Investigational Site

Ipoh, 30450, Malaysia

GSK Investigational Site

Kuala Lumpur, 50603, Malaysia

GSK Investigational Site

Kuala Pahang, 28000, Malaysia

GSK Investigational Site

Kuantan, 25100, Malaysia

GSK Investigational Site

Lumut, 32040, Malaysia

GSK Investigational Site

Saltillo, Coahuila CP 25230, Mexico

GSK Investigational Site

Torreón, Coahuila 27000, Mexico

GSK Investigational Site

Durango, Durango 34000, Mexico

GSK Investigational Site

León, Guanajuato 37000, Mexico

GSK Investigational Site

León, Guanajuato 37530, Mexico

GSK Investigational Site

Guadalajara, Jalisco 44600, Mexico

GSK Investigational Site

Guadalajara, Jalisco 44620, Mexico

GSK Investigational Site

Cuernavaca, Morelos 62448, Mexico

GSK Investigational Site

Monterrey, Nuevo León 64000, Mexico

GSK Investigational Site

Querétaro City, Querétaro 76000, Mexico

GSK Investigational Site

Culiacán, Sinaloa 80200, Mexico

GSK Investigational Site

Culiacán, Sinaloa 80230, Mexico

GSK Investigational Site

Mazatlán, Sinaloa 82020, Mexico

GSK Investigational Site

Ciudad de Mexico, State of Mexico 14080, Mexico

GSK Investigational Site

Mérida, Yucatán 97133, Mexico

GSK Investigational Site

Mérida, Yucatán CP 97070, Mexico

GSK Investigational Site

Aguascalientes, 20230, Mexico

GSK Investigational Site

Chihuahua City, 31203, Mexico

GSK Investigational Site

Chihuahua City, 31217, Mexico

GSK Investigational Site

Culiacán, 80030, Mexico

GSK Investigational Site

Mexico City, 06100, Mexico

GSK Investigational Site

Mexico City, ?03800, Mexico

GSK Investigational Site

Tlalnepantla, 54055, Mexico

GSK Investigational Site

Veracruz, 91020, Mexico

GSK Investigational Site

Zapopan, Jalisco, 45030, Mexico

GSK Investigational Site

Amsterdam, 1081 HV, Netherlands

GSK Investigational Site

Deventer, 7416 SE, Netherlands

GSK Investigational Site

Rotterdam, 3079 DZ, Netherlands

GSK Investigational Site

Dunedin, 9016, New Zealand

GSK Investigational Site

Hamilton, 2001, New Zealand

GSK Investigational Site

Hastings, 4156, New Zealand

GSK Investigational Site

Otahuhu, 1640, New Zealand

GSK Investigational Site

Takapuna, Auckland, ?0740, New Zealand

GSK Investigational Site

Baguio City, Benguet, 2600, Philippines

GSK Investigational Site

Cebu City, 6000, Philippines

GSK Investigational Site

Dasmariñas, 4114, Philippines

GSK Investigational Site

Iloilo City, 5000, Philippines

GSK Investigational Site

Manila, 1000, Philippines

GSK Investigational Site

Pasig, 1605, Philippines

GSK Investigational Site

Quezon City, 1100, Philippines

GSK Investigational Site

San Juan City, 1500, Philippines

GSK Investigational Site

Sto Tomas, 4234, Philippines

GSK Investigational Site

Bialystok, 15-540, Poland

GSK Investigational Site

Brzeg, 49301, Poland

GSK Investigational Site

Gdansk, 80-952, Poland

GSK Investigational Site

Katowice, 40-027, Poland

GSK Investigational Site

Kielce, 25-736, Poland

GSK Investigational Site

Kołobrzeg, 78-100, Poland

GSK Investigational Site

Lodz, 92-213, Poland

GSK Investigational Site

Radom, 26-610, Poland

GSK Investigational Site

Szczecin, 70-111, Poland

GSK Investigational Site

Żyrardów, 96-300, Poland

GSK Investigational Site

Amadora, 2720-276, Portugal

GSK Investigational Site

Aveiro, 3814-501, Portugal

GSK Investigational Site

Covilha, 6200-000, Portugal

GSK Investigational Site

Lisbon, 1069-166, Portugal

GSK Investigational Site

Lisbon, 1250-189, Portugal

GSK Investigational Site

Lisbon, 1400-195, Portugal

GSK Investigational Site

Torres Novas, 2350-754, Portugal

GSK Investigational Site

Bucharest, 022328, Romania

GSK Investigational Site

Bucharest, ?022328, Romania

GSK Investigational Site

Bucharest, ?042122, Romania

GSK Investigational Site

Constanța, 900591, Romania

GSK Investigational Site

Oradea, 410469, Romania

GSK Investigational Site

Timișoara, 300723, Romania

GSK Investigational Site

Irkutsk, 664049, Russia

GSK Investigational Site

Kemerovo, 650060, Russia

GSK Investigational Site

Krasnodar, 350029, Russia

GSK Investigational Site

Moscow, 119121, Russia

GSK Investigational Site

Mytischi, 141009, Russia

GSK Investigational Site

Omsk, 644112, Russia

GSK Investigational Site

Podolsk, 142110, Russia

GSK Investigational Site

Ryazan, 390026, Russia

GSK Investigational Site

Saint Petersburg, 194104, Russia

GSK Investigational Site

Saint Petersburg, 196247, Russia

GSK Investigational Site

Smolensk, 214006, Russia

GSK Investigational Site

Ulyanovsk, 432063, Russia

GSK Investigational Site

Volzhsky, 404120, Russia

GSK Investigational Site

Yaroslavl, 150062, Russia

GSK Investigational Site

Singapore, 119074, Singapore

GSK Investigational Site

Singapore, 169608, Singapore

GSK Investigational Site

Singapore, 308433, Singapore

GSK Investigational Site

Singapore, 768828, Singapore

GSK Investigational Site

Port Elizabeth, Eastern Cape 6001, South Africa

GSK Investigational Site

Cape Town, 7500, South Africa

GSK Investigational Site

Cape Town, 7925, South Africa

GSK Investigational Site

Somerset West, 7130, South Africa

GSK Investigational Site

Anyang-Si, Gyeonggi-do, 14068, South Korea

GSK Investigational Site

Bucheon-si, 420-767, South Korea

GSK Investigational Site

Busan, 48108, South Korea

GSK Investigational Site

Daegu, 41931, South Korea

GSK Investigational Site

Daegu, 41944, South Korea

GSK Investigational Site

Daejeon, 301-721, South Korea

GSK Investigational Site

Goyang-si, 10444, South Korea

GSK Investigational Site

Ilsanseo-gu, Goyang-si,, 10380, South Korea

GSK Investigational Site

Incheon, 021431, South Korea

GSK Investigational Site

Incheon, 405-760, South Korea

GSK Investigational Site

Jeonju, 54987, South Korea

GSK Investigational Site

Seongnam, 13620, South Korea

GSK Investigational Site

Seoul, 06973, South Korea

GSK Investigational Site

Seoul, 07061, South Korea

GSK Investigational Site

Seoul, 08308, South Korea

GSK Investigational Site

Seoul, 134-727, South Korea

GSK Investigational Site

Seoul, 135-710, South Korea

GSK Investigational Site

Seoul, 137-701, South Korea

GSK Investigational Site

Seoul, 158-710, South Korea

GSK Investigational Site

Seoul, 3080, South Korea

GSK Investigational Site

Seoul, ?02447, South Korea

GSK Investigational Site

Seoul, ?05355, South Korea

GSK Investigational Site

Suwon, 16499, South Korea

GSK Investigational Site

Suwon, 442-723, South Korea

GSK Investigational Site

Uijeongbu-si, 11765, South Korea

GSK Investigational Site

Wŏnju, 26426, South Korea

GSK Investigational Site

Majadahonda, Madrid 28222, Spain

GSK Investigational Site

Badalona, 08916, Spain

GSK Investigational Site

Barcelona, 08003, Spain

GSK Investigational Site

Barcelona, 08011, Spain

GSK Investigational Site

Barcelona, 08025, Spain

GSK Investigational Site

Barcelona, 08035, Spain

GSK Investigational Site

Burela de Cabo, 27880, Spain

GSK Investigational Site

Cáceres, 10003, Spain

GSK Investigational Site

Ciudad Real, 13002, Spain

GSK Investigational Site

Girona, 17007, Spain

GSK Investigational Site

Guadalajara, 19002, Spain

GSK Investigational Site

L'Hospitalet de Llobregat, 08907, Spain

GSK Investigational Site

Mollet del Vallès, ?08100, Spain

GSK Investigational Site

Santiago de Compostela, 15706, Spain

GSK Investigational Site

Seville, 41071, Spain

GSK Investigational Site

Örebro, SE-701 85, Sweden

GSK Investigational Site

Stockholm, SE-141 86, Sweden

GSK Investigational Site

Uppsala, SE-75185, Sweden

GSK Investigational Site

Kaohsiung City, 807, Taiwan

GSK Investigational Site

Kaohsiung City, 833, Taiwan

GSK Investigational Site

Keelung, 204, Taiwan

GSK Investigational Site

New Taipei City, 220, Taiwan

GSK Investigational Site

Tainan, 704, Taiwan

GSK Investigational Site

Taipei, 10002, Taiwan

GSK Investigational Site

Taipei, 104, Taiwan

GSK Investigational Site

Taipei, 112, Taiwan

GSK Investigational Site

Taipei, 116, Taiwan

GSK Investigational Site

Taoyuan Hsien, 333, Taiwan

GSK Investigational Site

Bangkok, 10330, Thailand

GSK Investigational Site

Bangkok, 10400, Thailand

GSK Investigational Site

Bangkok, 11000, Thailand

GSK Investigational Site

Bangkoknoi, 10700, Thailand

GSK Investigational Site

Chiang Mai, 50200, Thailand

GSK Investigational Site

Khon Kaen, 40002, Thailand

GSK Investigational Site

Pathum Thani, 12120, Thailand

GSK Investigational Site

Adana, ?01330, Turkey (Türkiye)

GSK Investigational Site

Ankara, ?06100, Turkey (Türkiye)

GSK Investigational Site

Antalya, ?07059, Turkey (Türkiye)

GSK Investigational Site

Edirne, 22030, Turkey (Türkiye)

GSK Investigational Site

Eskişehir, 26480, Turkey (Türkiye)

GSK Investigational Site

Istanbul, 34130, Turkey (Türkiye)

GSK Investigational Site

Istanbul, 34381, Turkey (Türkiye)

GSK Investigational Site

Istanbul, 34899, Turkey (Türkiye)

GSK Investigational Site

Kayseri, 38039, Turkey (Türkiye)

GSK Investigational Site

Cherkasy, 18009, Ukraine

GSK Investigational Site

Chernihiv, 14029, Ukraine

GSK Investigational Site

Chernivtsi, 58005, Ukraine

GSK Investigational Site

Ivano-Frankivsk, 76008, Ukraine

GSK Investigational Site

Kharkiv, 61039, Ukraine

GSK Investigational Site

Kherson, 73039, Ukraine

GSK Investigational Site

Kiev, ?04107, Ukraine

GSK Investigational Site

Kyiv, 01014, Ukraine

GSK Investigational Site

Kyiv, 04112, Ukraine

GSK Investigational Site

Kyiv, ?01023, Ukraine

GSK Investigational Site

Kyiv, ?04050, Ukraine

GSK Investigational Site

Lutsk, 43000, Ukraine

GSK Investigational Site

Mykolaiv, 54058, Ukraine

GSK Investigational Site

Poltava, 36011, Ukraine

GSK Investigational Site

Ternopil, 46002, Ukraine

GSK Investigational Site

Zaporizhzhya, 69001, Ukraine

GSK Investigational Site

Zaporizhzhya, 69600, Ukraine

GSK Investigational Site

Zhytomyr, 10002, Ukraine

GSK Investigational Site

Stevenage, Hertfordshire SG1 4AB, United Kingdom

GSK Investigational Site

Preston, Lancashire PR2 9HT, United Kingdom

GSK Investigational Site

Hampstead, London NW3 2QG, United Kingdom

GSK Investigational Site

Liverpool, Merseyside L7 8XP, United Kingdom

GSK Investigational Site

Wolverhampton, West Midlands WV10 0QP, United Kingdom

GSK Investigational Site

Birmingham, B9 5SS, United Kingdom

GSK Investigational Site

Bristol, BS10 5NB, United Kingdom

GSK Investigational Site

Cambridge, CB2 0QQ, United Kingdom

GSK Investigational Site

Cardiff, CF14 4XW, United Kingdom

GSK Investigational Site

Derby, DE22 3NE, United Kingdom

GSK Investigational Site

Doncaster, DN2 5LT, United Kingdom

GSK Investigational Site

Fife, KY2 5AH, United Kingdom

GSK Investigational Site

Glasgow, G51 4TF, United Kingdom

GSK Investigational Site

Hull, HU3 2JZ, United Kingdom

GSK Investigational Site

Leeds, LS9 7TF, United Kingdom

GSK Investigational Site

London, E1 1BB, United Kingdom

GSK Investigational Site

London, SE5 9RS, United Kingdom

GSK Investigational Site

Manchester, M13 9WL, United Kingdom

GSK Investigational Site

Middlesbrough, TS4 3BW, United Kingdom

GSK Investigational Site

Oxford, OX3 7LE, United Kingdom

GSK Investigational Site

Salford, M6 8HD, United Kingdom

GSK Investigational Site

York, YO31 8HE, United Kingdom

GSK Investigational Site

Haiphong, 180000, Vietnam

GSK Investigational Site

Hanoi, 11000, Vietnam

GSK Investigational Site

Hà Nội, 10000, Vietnam

GSK Investigational Site

Ho Chi Minh City, 700000, Vietnam