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| Name | Class |
|---|---|
| Janssen Research & Development, LLC | INDUSTRY |
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The main objective of the study is to assess preferences of Non Valvular Atrial Fibrillation (NVAF) patients towards different options of an anticoagulation treatment.
Patient preferences for anticoagulant treatment attributes (convenience attributes only), based on a Discrete Choice Experiment(DCE) interview will be elicited and the impact of switching from Vitamin K Antagonist(VKA) to Xarelto® on Atrial Fibrilation(AF) patient treatment satisfaction will be documented, measured by score differences of the Anti-Clot Treatment Scale (ACTS) score in patients switching from VKA to Rivaroxaban.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rivaroxaban, BAY59-7939 | It is a single-arm study in which only patients who switched from a VKA to a NOAC treatment will be included. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rivaroxaban (Xarelto, BAY 59-7939) | Drug | No specified dosing or dosage in the study. The treatment decision falls within current practice and the prescription of the medicines is clearly separated from the decision to include the patient in the study. |
| Measure | Description | Time Frame |
|---|---|---|
| Patient preferences for anticoagulant treatment attributes (utility values obtained in Logit/Probit estimates) | The preferred attributes will be assessed by a questionnaire following a discrete choice experimental design. | At 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change of the Anti-clot treatment scale (ACTS) benefit and burden score from baseline (on VKA) to 3 months (on Xarelto) | ACTS = Anti Clot treatment Scale is a questionnaire of 17 items (13 items on burden of treatment and 4 items on the benefits of treatment) | At 0 month and at 3 months |
| AF symptoms as measured by European Heart Rhythm Association (EHRA) symtoms (both severity and frequency) |
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Inclusion Criteria:
Exclusion Criteria:
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A total of 300 patients will be included in this study. Participating centers are either primary care practices, internal medicine specialist practices or out-patient sites/out-patient clinics
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| Name | Affiliation | Role |
|---|---|---|
| Bayer Study Director | Bayer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Many Locations | Multiple Locations | Taiwan |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D000069552 | Rivaroxaban |
| ID | Term |
|---|---|
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D009025 | Morpholines |
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| At 3 months |
| Reasons for switch from VKA to Xarelto | The reasons are selected by the participant out of a qualitative list of reasons for switch from VKA to Xarelto. | At 0 month |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D010078 |
| Oxazines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |