Endoresection of the Tumor Scar or Transpupillary Thermotherapy for the Treatment of Large Uveal Melanomas (Endoresection-Laser)

Phase II Evaluating Endoresection of the Tumor Scar or Transpupillary Thermotherapy When Endoresection is Not Feasible After Proton Beam Therapy for the Treatment of Large Uveal Melanomas

Study the efficacy of endoresection of the tumor scar or, when surgery is not possible, transpupillary thermotherapy on the tumor scar to prevent neovascular glaucoma and secondary enucleation

Inclusion Criteria:

• Tumor of 7 mm of thickness or more
• Patients treated by proton beam therapy
• Patients aged at least 18 years
• Patients clearly informed of the study, having received the letter of information and signed the consent

Exclusion Criteria:

• Massive extrascleral extension posterior to the equator
• Patients with metastasis at diagnosis.
• Patients with glaucoma before the radiation therapy
• Patients with opaque media preventing transpupillary thermotherapy
• Patients for whom follow up will be difficult due to geographical, social or psychological reasons