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The purposes of this study were to investigate the prevalence and risk factors for sarcopenia in Chinese adults and elderly, and evaluate the effect of Lifestyle Modification Project (LMP) on Clinical Outcomes, Quality of Life and Cost-effectiveness Ratio.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| nutritional intervention | Experimental | This group received multi-dimensional intensive nutritional intervention for 3 month, which included whey (30g/d,plus three times every week ),vitamin D (1000IU) and omega-3 fatty acid (DHA 1200mg and EPA 800mg). |
|
| resistance training program | Experimental | This group received resistance training program which is made up warm-up exercise, muscle strength training and relaxing. |
|
| lifestyle modification project | Experimental | This group receive multi-dimensional intensive nutritional intervention and resistance training program. |
|
| control | Placebo Comparator | This group receive nutritional consulting,which involve dietary pattern modification and protein intake standardization. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nutritional intervention | Behavioral | The intervention is made up of nutrition supplements and dietary pattern modification, which includes whey 30g/d(plus three times every week),vitamin D 1000IU, omega-3 fatty acid (DHA1200mg and EPA 800mg) |
| Measure | Description | Time Frame |
|---|---|---|
| relative skeletal muscle index | RSMI(Unit: kg/m2)is defined as muscle mass | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Hand grip | HG(Unit: kg)is defined as muscle strength | 3 months |
| gait speed | GP(Unit: s)is defined as physical activity level | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
Participants received any drugs or supplements known to influence effcet size,such as protein powder, calcium, or vitamin D before the 3 months preceding the study. Participants with electronic or mental device
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kang Yu | Contact | +86 10 69155550 | yuk1997@sina.com |
| Name | Affiliation | Role |
|---|---|---|
| Kang Yu | Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking Union Medical College Hospital | Recruiting | Beijing | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41126316 | Derived | Li CW, Li Q, Liu Y, Zhang Y, Wang ZK, Xing Y, Niu YS, Pang Y, Yu K. Sarcopenic obesity exacerbates gastric cancer prognosis via increased intermuscular and visceral fat accumulation. Eur J Med Res. 2025 Oct 22;30(1):1012. doi: 10.1186/s40001-025-03251-6. | |
| 33216623 | Derived | Li Z, Cui M, Yu K, Zhang XW, Li CW, Nie XD, Wang F. Effects of nutrition supplementation and physical exercise on muscle mass, muscle strength and fat mass among sarcopenic elderly: a randomized controlled trial. Appl Physiol Nutr Metab. 2021 May;46(5):494-500. doi: 10.1139/apnm-2020-0643. Epub 2020 Nov 20. |
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| resistance training program | Behavioral | The training program involve warm-up exercise, muscle strength training and relaxing |
|
| lifestyle modification project | Behavioral | Lifestyle modification project is made up of multi-dimensional intensive nutritional intervention and resistance training |
|
| control | Behavioral | The intervention involve dietary pattern modification and protein intake standardization |
|
| quality of life on EQ-5D scale | Scores range from 0 [worse] to 1[best](Unit on a scale) | 3 months |
| The rate of fracture | rate of participants with fracture due to fall(Unit: %) | 3 months |
| the change of physical function on frail index | Scores range from 0 [normal] to 1[unhealth](Unit on a scale) | 3 months |
| the rate of infection complication | Rate of participants with infection complication due to sarcopenia(Unit: %) | 3 months |
| mortality rate | Rate of participants mortality(Unit: %) | 3 months |
| medical cost on cost-effectiveness ratio | the lower cost，the higher effectiveness(Unit: %) | 3 months |
| 30969486 | Derived | Li CW, Yu K, Shyh-Chang N, Li GX, Jiang LJ, Yu SL, Xu LY, Liu RJ, Guo ZJ, Xie HY, Li RR, Ying J, Li K, Li DJ. Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):586-600. doi: 10.1002/jcsm.12417. Epub 2019 Apr 10. |
| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
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