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| Name | Class |
|---|---|
| Centre Hospitalier Universitaire Dijon | OTHER |
| Assistance Publique - Hôpitaux de Paris | OTHER |
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The purpose of this study is to evaluate the effect of 10 sessions of anodal transcranial Direct Current Stimulation (tDCS - 1 mA) applied to left Cortex DorsoLateral PreFrontal (CDLPF) of Alzheimer's or Primary Progressive Aphasia (PPA) patients compared to the application of a placebo tDCS (sham procedure) on cognitive functions, which are evaluated at short term (1 week post-treatment) and mild term (3 weeks post-treatment).
After unblinding, patients who received placebo treatment could be received active tDCS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| anodal tDCS on left DLPFC (F3) | Active Comparator | tDCS is a non-invasive neuromodulation method, which delivers a constant current of low intensity (1 mA) during 30 minutes for 10 sessions. Anode is placed on the scalp facing on left DLPFC (F3) and cathode between Fp2-F8 EEG-repair. |
|
| sham tDCS on left DLPFC (F3) | Sham Comparator | Sham tDCS differs from active tDCS by the interruption of stimulation after 15 sec and reactivation of the stimulation 15 sec before the end of the session (30 minutes - 10 sessions. Anode is placed on the scalp facing on left DLPFC (F3) and cathode between Fp2-F8 EEG-repair. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial Direct Current Stimulation (tDCS) | Device | After locating the stimulation areas, treatment will be delivered during 30-minute session. Treatment will be occur 2 session per day during 5 consecutive days. Subjects will be monitored during tDCS sessions for any side effects or adverse events. |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline cognitive functions at 3 weeks | neuropsychological assessments include Rapid battery tests (Bereay et al., 2015) | baseline, day 5 and 3 weeks post-tDCS |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pierre Vandel, MD PhD | Contact | +33381219007 | pierre.vandel@univ-fcomte.fr | |
| Magali Nicolier, PhD | Contact | +33381219007 | mnicolier@chu-besancon.fr |
| Name | Affiliation | Role |
|---|---|---|
| Claire Paquet, MD PhD | Assitance Publique - Hôpitaux Paris | Principal Investigator |
| Bernard Bonnin, MD PhD | Centre Hospitalier Universaitaire Dijon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Besancon - Clinical Psychiatric Department | Recruiting | Besançon | 25000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26212200 | Background | Bereau M, Sylvestre G, Mauny F, Puyraveau M, Baudier F, Magnin E, Berger E, Vandel P, Galmiche J, Chopard G. [Assessment of 10 years of memory consultations in the Franche-Comte: Description and analysis of the RAPID regional database]. Rev Neurol (Paris). 2015 Sep;171(8-9):655-61. doi: 10.1016/j.neurol.2015.04.008. Epub 2015 Jul 23. French. |
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| Hopital Universitaire Dijon | Not yet recruiting | Dijon | France |
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| Assistance Publique - Hôpitaux Paris | Recruiting | Paris | France |
|
| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D020774 | Pick Disease of the Brain |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D057180 | Frontotemporal Dementia |
| D057174 | Frontotemporal Lobar Degeneration |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
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