Efficacy Study of Nivolumab Plus Ipilimumab or Nivolumab... | NCT02872116

ID	Type	Description	Link
2016-001018-76	EudraCT Number

Name	Class
Ono Pharmaceutical Co., Ltd.	INDUSTRY

Label	Type	Description	Intervention Names
Nivolumab + Ipilimumab	Experimental	Nivolumab + Ipilimumab for 4 doses, followed by Nivolumab monotherapy Enrollment is closed for this arm	Drug: Nivolumab Drug: Ipilimumab
XELOX (Oxaliplatin + Capecitabine)	Active Comparator		Drug: Oxaliplatin Drug: Capecitabine
FOLFOX (Oxaliplatin + Leucovorin + Fluorouracil)	Active Comparator		Drug: Oxaliplatin Drug: Leucovorin Drug: Fluorouracil
Nivolumab + XELOX	Experimental		Drug: Nivolumab Drug: Oxaliplatin Drug: Capecitabine
Nivolumab + FOLFOX	Experimental		Drug: Nivolumab Drug: Oxaliplatin Drug: Leucovorin Drug: Fluorouracil

Name	Type	Description	Arm Group Labels	Other Names
Nivolumab	Drug	Specified dose on specified days	Nivolumab + FOLFOX Nivolumab + Ipilimumab Nivolumab + XELOX

Measure	Description	Time Frame
Overall Survival (OS) in Participants Treated With Nivolumab Plus Chemotherapy vs Chemotherapy With PD-L1 CPS ≥ 5	Overall survival (OS), defined as the time from randomization to the time of death, in participants treated with Nivolumab plus Chemotherapy vs Chemotherapy with PD-L1 CPS (combined positive score) ≥ 5. CPS is defined as the number of PD-L1 staining cells (tumor cells, lymphocytes, macrophages) divided by the total number of viable tumor cells, multiplied by 100.	From the date of randomization up to the date of death, up to approximately 17 months
Progression Free Survival (PFS) in Participants Treated With Nivolumab Plus Chemotherapy vs Chemotherapy With PD-L1 CPS ≥ 5	Progression Free Survival (PFS) is defined as the time from randomization to the date of the first documented PD or death due to any cause. PD is determined by blinded independent committee review (BICR) per RECIST1.1 criteria in participants treated with Nivolumab plus Chemotherapy vs Chemotherapy with PD-L1 CPS ≥ 5. Progressive disease (PD) is defined as at least a 20% increase in the sum of diameters of target lesions, taking in reference the smallest sum on study that also demonstrated an absolute increase of at least 5 mm. CPS is defined as the number of PD-L1 staining cells (tumor cells, lymphocytes, macrophages) divided by the total number of viable tumor cells, multiplied by 100.	From randomization to the date of the first documented progressive disease (PD) per BICR or death due to any cause (up to approximately 10 months)

Measure	Description	Time Frame
OS in Participants Treated With Nivolumab Plus Chemotherapy vs Chemotherapy	Overall survival (OS), defined as the time from randomization to the time of death, in participants treated with Nivolumab plus Chemotherapy vs Chemotherapy with PD-L1 CPS ≥ 1, 10, and all randomized participants. CPS is defined as the number of PD-L1 staining cells (tumor cells, lymphocytes, macrophages) divided by the total number of viable tumor cells, multiplied by 100.

Name	Affiliation	Role
Bristol-Myers Squibb	Bristol-Myers Squibb	Study Director

Facility	Status	City	State	ZIP	Country	Contacts
Local Institution - 0005		Los Angeles	California	90033	United States
Local Institution - 0001

PubMed Identifier	Type	Citation	Retractions
40632415	Derived	Lin D, Quan W, Garretson M, Chirikov V, Chen C, Singh P, Davis C, Sugarman R. Q-TWiST analysis of first-line nivolumab plus chemotherapy versus chemotherapy in patients with advanced gastric cancer, gastroesophageal junction cancer, or esophageal adenocarcinoma from CheckMate 649: 4-year follow-up results. Gastric Cancer. 2025 Sep;28(5):935-944. doi: 10.1007/s10120-025-01634-6. Epub 2025 Jul 9.
38382001

Label	URL
BMS Clinical Trial Information	View source

ID	Title	Description
FG000	Arm 1: Nivolumab + Chemotherapy (XELOX or FOLFOX)	Nivolumab + Xelox: Nivolumab 360 mg IV over 30 minutes on Day 1 of each treatment cycle, every 3 weeks + Oxaliplatin 130 mg/m2 IV on Day 1 of each treatment cycle + capecitabine 1000 mg/m2 orally twice daily (ie, 1000 mg/m2 in the morning and 1000 mg/m2 in the evening) on Days 1 to 14 of each treatment cycle, every 3 weeks Nivolumab + Folfox: Nivolumab 240 mg IV over 30 minutes on Day 1 of each treatment cycle, every 2 weeks + Oxaliplatin 85 mg/m2 + leucovorin 400 mg/m2 + fluorouracil 400 mg/m2 IV on Day 1 of each treatment cycle, and fluorouracil 1200 mg/m2 IV continuous infusion over 24 hours (or per local standard) daily on Days 1 and 2 of each treatment cycle, every 2 weeks

Type	Includes Protocol	Includes SAP	Includes ICF	Document Label	Document Date	Document Uploaded Date	Document File Name
Prot	Yes	No	No	Study Protocol	Sep 16, 2019	May 18, 2022

Serious Adverse Events

Term	Organ System	Source Vocabulary	Assessment Type	Statistical Information
Anaemia	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG00028 affected782 at risk EG00117 affected806 at risk EG00213 affected403 at risk
Blood loss anaemia	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Bone marrow failure	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Disseminated intravascular coagulation	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Febrile bone marrow aplasia	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Febrile neutropenia	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG00020 affected782 at risk EG00110 affected806 at risk EG0021 affected403 at risk
Immune thrombocytopenia	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Leukocytosis	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Leukopenia	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Lymphadenopathy	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Myelosuppression	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0004 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Neutropenia	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0004 affected782 at risk EG0013 affected806 at risk EG0020 affected403 at risk
Pancytopenia	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Splenic haematoma	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Thrombocytopenia	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0004 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Thrombotic microangiopathy	Blood and lymphatic system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Acute coronary syndrome	Cardiac disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Acute myocardial infarction	Cardiac disorders	24.0	Systematic Assessment	EG0004 affected782 at risk EG0013 affected806 at risk EG0021 affected403 at risk
Angina pectoris	Cardiac disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Angina unstable	Cardiac disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Arrhythmia	Cardiac disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Atrial fibrillation	Cardiac disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Atrioventricular block complete	Cardiac disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Autoimmune myocarditis	Cardiac disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Cardiac arrest	Cardiac disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Cardiac failure	Cardiac disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Cardiac failure acute	Cardiac disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cardiac failure congestive	Cardiac disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cardiac tamponade	Cardiac disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Cardio-respiratory arrest	Cardiac disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Myocardial infarction	Cardiac disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0015 affected806 at risk EG0023 affected403 at risk
Myocarditis	Cardiac disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Pericardial effusion	Cardiac disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0013 affected806 at risk EG0021 affected403 at risk
Supraventricular extrasystoles	Cardiac disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Supraventricular tachycardia	Cardiac disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Tachyarrhythmia	Cardiac disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Tachycardia	Cardiac disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Choledochal cyst	Congenital, familial and genetic disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Microvillous inclusion disease	Congenital, familial and genetic disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Pyloric stenosis	Congenital, familial and genetic disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Tracheo-oesophageal fistula	Congenital, familial and genetic disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Vertigo	Ear and labyrinth disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Adrenal insufficiency	Endocrine disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0024 affected403 at risk
Autoimmune thyroiditis	Endocrine disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hyperthyroidism	Endocrine disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hypophysitis	Endocrine disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0024 affected403 at risk
Hypopituitarism	Endocrine disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hypothalamo-pituitary disorder	Endocrine disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hypothyroidism	Endocrine disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Immune-mediated hypophysitis	Endocrine disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Inappropriate antidiuretic hormone secretion	Endocrine disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Secondary adrenocortical insufficiency	Endocrine disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Thyroiditis	Endocrine disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Cataract	Eye disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Ocular vasculitis	Eye disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Visual impairment	Eye disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Abdominal adhesions	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Abdominal distension	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Abdominal hernia	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Abdominal pain	Gastrointestinal disorders	24.0	Systematic Assessment	EG00012 affected782 at risk EG00113 affected806 at risk EG0024 affected403 at risk
Abdominal pain lower	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Abdominal pain upper	Gastrointestinal disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Ascites	Gastrointestinal disorders	24.0	Systematic Assessment	EG00015 affected782 at risk EG0019 affected806 at risk EG0026 affected403 at risk
Autoimmune colitis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Colitis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0006 affected782 at risk EG0010 affected806 at risk EG00211 affected403 at risk
Constipation	Gastrointestinal disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0013 affected806 at risk EG0022 affected403 at risk
Cyclic vomiting syndrome	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Diarrhoea	Gastrointestinal disorders	24.0	Systematic Assessment	EG00021 affected782 at risk EG00114 affected806 at risk EG00213 affected403 at risk
Diverticulum intestinal haemorrhagic	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Duodenal obstruction	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Duodenal perforation	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Dyspepsia	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Dysphagia	Gastrointestinal disorders	24.0	Systematic Assessment	EG00013 affected782 at risk EG00123 affected806 at risk EG0029 affected403 at risk
Enteritis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Enterocolitis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0004 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Gastric haemorrhage	Gastrointestinal disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG00111 affected806 at risk EG0024 affected403 at risk
Gastric perforation	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0013 affected806 at risk EG0021 affected403 at risk
Gastric stenosis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastric ulcer	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Gastrointestinal fistula	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Gastrointestinal haemorrhage	Gastrointestinal disorders	24.0	Systematic Assessment	EG00013 affected782 at risk EG0019 affected806 at risk EG0024 affected403 at risk
Gastrointestinal inflammation	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastrointestinal necrosis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastrointestinal obstruction	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Gastrointestinal perforation	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastrointestinal stenosis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Gastrooesophageal reflux disease	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Haematemesis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Haematochezia	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Haemoperitoneum	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Ileus	Gastrointestinal disorders	24.0	Systematic Assessment	EG0004 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Ileus paralytic	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Immune-mediated enterocolitis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG00211 affected403 at risk
Impaired gastric emptying	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Intestinal haemorrhage	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Intestinal obstruction	Gastrointestinal disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0016 affected806 at risk EG0022 affected403 at risk
Intestinal perforation	Gastrointestinal disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Intestinal stenosis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Large intestinal haemorrhage	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Large intestinal stenosis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Large intestine perforation	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Lower gastrointestinal haemorrhage	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Malabsorption	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Malignant gastrointestinal obstruction	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Melaena	Gastrointestinal disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Nausea	Gastrointestinal disorders	24.0	Systematic Assessment	EG0008 affected782 at risk EG00110 affected806 at risk EG0027 affected403 at risk
Obstruction gastric	Gastrointestinal disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0015 affected806 at risk EG0025 affected403 at risk
Obstructive pancreatitis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Oesophageal compression	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oesophageal fistula	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Oesophageal haemorrhage	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Oesophageal obstruction	Gastrointestinal disorders	24.0	Systematic Assessment	EG0004 affected782 at risk EG0013 affected806 at risk EG0024 affected403 at risk
Oesophageal pain	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Oesophageal stenosis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Oesophageal ulcer haemorrhage	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oesophageal varices haemorrhage	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oesophagitis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pancreatitis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Pancreatitis acute	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Peritoneal adhesions	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Prepyloric stenosis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Proctitis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Retroperitoneal haematoma	Gastrointestinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Small intestinal obstruction	Gastrointestinal disorders	24.0	Systematic Assessment	EG0004 affected782 at risk EG0015 affected806 at risk EG0020 affected403 at risk
Stomatitis	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Subileus	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Thrombosis mesenteric vessel	Gastrointestinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Upper gastrointestinal haemorrhage	Gastrointestinal disorders	24.0	Systematic Assessment	EG00017 affected782 at risk EG00110 affected806 at risk EG00213 affected403 at risk
Vomiting	Gastrointestinal disorders	24.0	Systematic Assessment	EG00029 affected782 at risk EG00124 affected806 at risk EG00212 affected403 at risk
Asthenia	General disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0015 affected806 at risk EG0023 affected403 at risk
Catheter site extravasation	General disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Catheter site haemorrhage	General disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Chest discomfort	General disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Complication associated with device	General disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Death	General disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Disease progression	General disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0014 affected806 at risk EG0020 affected403 at risk
Effusion	General disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Euthanasia	General disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Face oedema	General disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Fatigue	General disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0012 affected806 at risk EG0026 affected403 at risk
Gait disturbance	General disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
General physical health deterioration	General disorders	24.0	Systematic Assessment	EG0005 affected782 at risk EG0017 affected806 at risk EG0023 affected403 at risk
Generalised oedema	General disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Inflammation	General disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Malaise	General disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0013 affected806 at risk EG0021 affected403 at risk
Mucosal inflammation	General disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Multiple organ dysfunction syndrome	General disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Non-cardiac chest pain	General disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oedema peripheral	General disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Pain	General disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0014 affected806 at risk EG0020 affected403 at risk
Performance status decreased	General disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Peripheral swelling	General disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pyrexia	General disorders	24.0	Systematic Assessment	EG00022 affected782 at risk EG00111 affected806 at risk EG0029 affected403 at risk
Sudden death	General disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0013 affected806 at risk EG0022 affected403 at risk
Systemic inflammatory response syndrome	General disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Ulcer haemorrhage	General disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Acute hepatic failure	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Autoimmune hepatitis	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0026 affected403 at risk
Bile duct stenosis	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Bile duct stone	Hepatobiliary disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Biliary obstruction	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Cholangitis	Hepatobiliary disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cholangitis acute	Hepatobiliary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Cholecystitis	Hepatobiliary disorders	24.0	Systematic Assessment	EG0005 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Cholecystitis acute	Hepatobiliary disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Cholecystitis chronic	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cholestasis	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Drug-induced liver injury	Hepatobiliary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0025 affected403 at risk
Hepatic cyst ruptured	Hepatobiliary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hepatic failure	Hepatobiliary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Hepatic function abnormal	Hepatobiliary disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0012 affected806 at risk EG0025 affected403 at risk
Hepatitis	Hepatobiliary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0025 affected403 at risk
Hepatitis acute	Hepatobiliary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hepatitis toxic	Hepatobiliary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hepatorenal failure	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Hepatotoxicity	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hyperbilirubinaemia	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hypertransaminasaemia	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Immune-mediated hepatic disorder	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Immune-mediated hepatitis	Hepatobiliary disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Jaundice	Hepatobiliary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Jaundice cholestatic	Hepatobiliary disorders	24.0	Systematic Assessment	EG0006 affected782 at risk EG0013 affected806 at risk EG0022 affected403 at risk
Jaundice extrahepatic obstructive	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Liver disorder	Hepatobiliary disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Liver injury	Hepatobiliary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Portal hypertension	Hepatobiliary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Anaphylactic reaction	Immune system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Contrast media allergy	Immune system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Drug hypersensitivity	Immune system disorders	24.0	Systematic Assessment	EG0004 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Hypersensitivity	Immune system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Abdominal abscess	Infections and infestations	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Abdominal infection	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Abdominal sepsis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Amoebic colitis	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Anal abscess	Infections and infestations	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Appendicitis	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Appendicitis perforated	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Arthritis bacterial	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Asymptomatic COVID-19	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Bacteraemia	Infections and infestations	24.0	Systematic Assessment	EG0004 affected782 at risk EG0011 affected806 at risk EG0023 affected403 at risk
Biliary tract infection	Infections and infestations	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Bronchitis	Infections and infestations	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Bronchitis viral	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
COVID-19 pneumonia	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cellulitis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0013 affected806 at risk EG0022 affected403 at risk
Chorioretinitis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Clostridium difficile colitis	Infections and infestations	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Clostridium difficile infection	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Cystitis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Dengue fever	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Device related infection	Infections and infestations	24.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Device related sepsis	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Diarrhoea infectious	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Diverticulitis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Encephalitis	Infections and infestations	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Endocarditis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Endophthalmitis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Enteritis infectious	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Enterocolitis infectious	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Epididymitis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Febrile infection	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Giardiasis	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hepatitis C	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Herpes simplex reactivation	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Herpes virus infection	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Infection	Infections and infestations	24.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Influenza	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Intervertebral discitis	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Large intestine infection	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Localised infection	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Lower respiratory tract infection	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Lung abscess	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Lymphangitis	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Mycobacterium avium complex infection	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Neutropenic infection	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Neutropenic sepsis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Oesophageal candidiasis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Osteomyelitis	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Parainfluenzae virus infection	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Peritonitis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Peritonitis bacterial	Infections and infestations	24.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pneumonia	Infections and infestations	24.0	Systematic Assessment	EG00030 affected782 at risk EG00121 affected806 at risk EG00213 affected403 at risk
Pneumonia bacterial	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pneumonia klebsiella	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pneumonia pneumococcal	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pneumonia viral	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Psoas abscess	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pulmonary sepsis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pyelonephritis	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Respiratory tract infection	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Sepsis	Infections and infestations	24.0	Systematic Assessment	EG00013 affected782 at risk EG0018 affected806 at risk EG0023 affected403 at risk
Septic shock	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Sialoadenitis	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Skin infection	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Soft tissue infection	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Staphylococcal infection	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Stoma site infection	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Streptococcal bacteraemia	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Tonsillitis	Infections and infestations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Tuberculous pleurisy	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Upper respiratory tract infection	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Urinary tract infection	Infections and infestations	24.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0026 affected403 at risk
Urosepsis	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Vascular device infection	Infections and infestations	24.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Viral infection	Infections and infestations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Anastomotic stenosis	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Craniocerebral injury	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Fall	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Femoral neck fracture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Femur fracture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Fracture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastroenteritis radiation	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Gastrointestinal stoma complication	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Heart injury	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Heat stroke	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hip fracture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Humerus fracture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Infusion related reaction	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0006 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Lower limb fracture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Lumbar vertebral fracture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Overdose	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG00011 affected782 at risk EG0016 affected806 at risk EG0020 affected403 at risk
Post procedural haematoma	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Procedural complication	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Radius fracture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Road traffic accident	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Skin laceration	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Soft tissue injury	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Spinal compression fracture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Spinal fracture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Subdural haematoma	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Synovial rupture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Thoracic vertebral fracture	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Vascular injury	Injury, poisoning and procedural complications	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Alanine aminotransferase increased	Investigations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Amylase increased	Investigations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Aspartate aminotransferase increased	Investigations	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Blood alkaline phosphatase increased	Investigations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Blood bilirubin increased	Investigations	24.0	Systematic Assessment	EG0006 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Blood corticotrophin decreased	Investigations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Blood creatinine increased	Investigations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Electrocardiogram ST segment elevation	Investigations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
General physical condition abnormal	Investigations	24.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Haemoglobin decreased	Investigations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hepatitis C virus test positive	Investigations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Lipase increased	Investigations	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Liver function test increased	Investigations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Neutrophil count decreased	Investigations	24.0	Systematic Assessment	EG0003 affected782 at risk EG0013 affected806 at risk EG0020 affected403 at risk
Platelet count decreased	Investigations	24.0	Systematic Assessment	EG0003 affected782 at risk EG0014 affected806 at risk EG0021 affected403 at risk
Transaminases increased	Investigations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Troponin increased	Investigations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Weight decreased	Investigations	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Decreased appetite	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0007 affected782 at risk EG0019 affected806 at risk EG0026 affected403 at risk
Dehydration	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0008 affected782 at risk EG0017 affected806 at risk EG0023 affected403 at risk
Diabetes mellitus	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Diabetes mellitus inadequate control	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Diabetic ketoacidosis	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Diabetic metabolic decompensation	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Electrolyte imbalance	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Failure to thrive	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gout	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hypercalcaemia	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Hyperglycaemia	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Hyperkalaemia	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Hypernatraemia	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hypoalbuminaemia	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Hypoglycaemia	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Hypokalaemia	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0015 affected806 at risk EG0022 affected403 at risk
Hyponatraemia	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0004 affected782 at risk EG0011 affected806 at risk EG0023 affected403 at risk
Hypophagia	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Hypoproteinaemia	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Malnutrition	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Metabolic acidosis	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Type 1 diabetes mellitus	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Type 2 diabetes mellitus	Metabolism and nutrition disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Arthralgia	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Arthritis	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Back pain	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0004 affected782 at risk EG0014 affected806 at risk EG0021 affected403 at risk
Bone lesion	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Bone pain	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Fistula	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Intervertebral disc protrusion	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Mixed connective tissue disease	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Muscular weakness	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Musculoskeletal chest pain	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Myositis	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0023 affected403 at risk
Osteolysis	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pain in extremity	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Pathological fracture	Musculoskeletal and connective tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Basal cell carcinoma	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Cancer pain	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Gastric cancer	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Gastric neoplasm	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Laryngeal squamous cell carcinoma	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Malignant ascites	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Malignant neoplasm progression	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG000246 affected782 at risk EG001242 affected806 at risk EG002112 affected403 at risk
Malignant pleural effusion	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Metastases to bone	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Metastases to central nervous system	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0004 affected782 at risk EG0014 affected806 at risk EG0020 affected403 at risk
Metastases to liver	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Metastases to meninges	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Metastasis	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Metastatic gastric cancer	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Myelodysplastic syndrome	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Neoplasm malignant	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Neoplasm progression	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Oesophageal adenocarcinoma	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oesophageal cancer metastatic	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Rectal cancer	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Second primary malignancy	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Squamous cell carcinoma	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Squamous cell carcinoma of lung	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Tumour associated fever	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Tumour haemorrhage	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Tumour necrosis	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Tumour obstruction	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Tumour pain	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Tumour ulceration	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Aphasia	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Brain oedema	Nervous system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Brain stem infarction	Nervous system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Central nervous system lesion	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cerebellar syndrome	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cerebral artery embolism	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Cerebral infarction	Nervous system disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Cerebral ischaemia	Nervous system disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cerebrovascular accident	Nervous system disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Depressed level of consciousness	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Diabetic hyperosmolar coma	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Dizziness	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Encephalitis autoimmune	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Encephalopathy	Nervous system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Epilepsy	Nervous system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Facial paresis	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Guillain-Barre syndrome	Nervous system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Headache	Nervous system disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Hemiparesis	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hypokinesia	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Immune-mediated neuropathy	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Intracranial pressure increased	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Ischaemic stroke	Nervous system disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Metabolic encephalopathy	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Neuritis	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Neuropathy peripheral	Nervous system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Polyneuropathy	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Presyncope	Nervous system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Seizure	Nervous system disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Spinal cord compression	Nervous system disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Subarachnoid haemorrhage	Nervous system disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Syncope	Nervous system disorders	24.0	Systematic Assessment	EG0009 affected782 at risk EG0014 affected806 at risk EG0022 affected403 at risk
Transient ischaemic attack	Nervous system disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Device breakage	Product Issues	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Device dislocation	Product Issues	24.0	Systematic Assessment	EG0003 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Device leakage	Product Issues	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Device malfunction	Product Issues	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Device occlusion	Product Issues	24.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Stent malfunction	Product Issues	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Bipolar disorder	Psychiatric disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Depression	Psychiatric disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Eating disorder	Psychiatric disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Mental status changes	Psychiatric disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Suicide attempt	Psychiatric disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Acute kidney injury	Renal and urinary disorders	24.0	Systematic Assessment	EG0006 affected782 at risk EG0013 affected806 at risk EG0029 affected403 at risk
Cystitis noninfective	Renal and urinary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Dysuria	Renal and urinary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Haematuria	Renal and urinary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hydronephrosis	Renal and urinary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Nephritis	Renal and urinary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Nephrolithiasis	Renal and urinary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Prerenal failure	Renal and urinary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Renal failure	Renal and urinary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0013 affected806 at risk EG0020 affected403 at risk
Renal impairment	Renal and urinary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Tubulointerstitial nephritis	Renal and urinary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Ureteric dilatation	Renal and urinary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Ureterolithiasis	Renal and urinary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Urinary retention	Renal and urinary disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Urinary tract obstruction	Renal and urinary disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Benign prostatic hyperplasia	Reproductive system and breast disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Vaginal haemorrhage	Reproductive system and breast disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Acute respiratory failure	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Asphyxia	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Bronchospasm	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Chronic obstructive pulmonary disease	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Cough	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Dyspnoea	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0023 affected403 at risk
Haemothorax	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hiccups	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Hypoxia	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Immune-mediated lung disease	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Interstitial lung disease	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Laryngeal haemorrhage	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Mediastinal effusion	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oropharyngeal discomfort	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pleural effusion	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0005 affected782 at risk EG0016 affected806 at risk EG0026 affected403 at risk
Pneumonia aspiration	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0005 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Pneumonitis	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG00019 affected782 at risk EG0011 affected806 at risk EG0027 affected403 at risk
Pneumothorax	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pulmonary artery thrombosis	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pulmonary embolism	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG00014 affected782 at risk EG00118 affected806 at risk EG0029 affected403 at risk
Pulmonary hypertension	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pulmonary oedema	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Respiratory failure	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0005 affected782 at risk EG0013 affected806 at risk EG0022 affected403 at risk
Restrictive pulmonary disease	Respiratory, thoracic and mediastinal disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Diabetic foot	Skin and subcutaneous tissue disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Drug eruption	Skin and subcutaneous tissue disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Eczema asteatotic	Skin and subcutaneous tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Ischaemic skin ulcer	Skin and subcutaneous tissue disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Rash	Skin and subcutaneous tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Rash erythematous	Skin and subcutaneous tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Rash maculo-papular	Skin and subcutaneous tissue disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Skin lesion	Skin and subcutaneous tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Toxic epidermal necrolysis	Skin and subcutaneous tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Urticaria	Skin and subcutaneous tissue disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastrectomy	Surgical and medical procedures	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Tumour excision	Surgical and medical procedures	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Axillary vein thrombosis	Vascular disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Capillary leak syndrome	Vascular disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Circulatory collapse	Vascular disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Deep vein thrombosis	Vascular disorders	24.0	Systematic Assessment	EG0003 affected782 at risk EG0013 affected806 at risk EG0023 affected403 at risk
Embolism	Vascular disorders	24.0	Systematic Assessment	EG0006 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Hypotension	Vascular disorders	24.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Hypovolaemic shock	Vascular disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Jugular vein thrombosis	Vascular disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Obstructive shock	Vascular disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Peripheral artery occlusion	Vascular disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Peripheral ischaemia	Vascular disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Peripheral venous disease	Vascular disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Shock	Vascular disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Shock haemorrhagic	Vascular disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Subclavian artery stenosis	Vascular disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Thrombosis	Vascular disorders	24.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Venous thrombosis	Vascular disorders	24.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Anaemia	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG00028 affected782 at risk EG00117 affected806 at risk EG00213 affected403 at risk
Blood loss anaemia	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Bone marrow failure	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Disseminated intravascular coagulation	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Febrile bone marrow aplasia	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Febrile neutropenia	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG00020 affected782 at risk EG00110 affected806 at risk EG0021 affected403 at risk
Immune thrombocytopenia	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Leukocytosis	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Leukopenia	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Lymphadenopathy	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Myelosuppression	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Neutropenia	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0013 affected806 at risk EG0020 affected403 at risk
Pancytopenia	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Splenic haematoma	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Thrombocytopenia	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Thrombotic microangiopathy	Blood and lymphatic system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Acute coronary syndrome	Cardiac disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Acute myocardial infarction	Cardiac disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0014 affected806 at risk EG0021 affected403 at risk
Angina pectoris	Cardiac disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Angina unstable	Cardiac disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Arrhythmia	Cardiac disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Atrial fibrillation	Cardiac disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Atrioventricular block complete	Cardiac disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Autoimmune myocarditis	Cardiac disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Cardiac arrest	Cardiac disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Cardiac failure	Cardiac disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Cardiac failure acute	Cardiac disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cardiac failure congestive	Cardiac disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cardiac tamponade	Cardiac disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Cardio-respiratory arrest	Cardiac disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Myocardial infarction	Cardiac disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0015 affected806 at risk EG0023 affected403 at risk
Myocardial injury	Cardiac disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Myocarditis	Cardiac disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Pericardial effusion	Cardiac disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0013 affected806 at risk EG0021 affected403 at risk
Supraventricular extrasystoles	Cardiac disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Supraventricular tachycardia	Cardiac disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Tachyarrhythmia	Cardiac disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Tachycardia	Cardiac disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Microvillous inclusion disease	Congenital, familial and genetic disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Pyloric stenosis	Congenital, familial and genetic disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Tracheo-oesophageal fistula	Congenital, familial and genetic disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Vertigo	Ear and labyrinth disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Adrenal insufficiency	Endocrine disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0024 affected403 at risk
Autoimmune thyroiditis	Endocrine disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hyperthyroidism	Endocrine disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hypophysitis	Endocrine disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0024 affected403 at risk
Hypopituitarism	Endocrine disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hypothalamo-pituitary disorder	Endocrine disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hypothyroidism	Endocrine disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Immune-mediated hypophysitis	Endocrine disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Inappropriate antidiuretic hormone secretion	Endocrine disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Secondary adrenocortical insufficiency	Endocrine disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Thyroiditis	Endocrine disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Cataract	Eye disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Ocular vasculitis	Eye disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Visual impairment	Eye disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Abdominal adhesions	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Abdominal distension	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Abdominal hernia	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Abdominal pain	Gastrointestinal disorders	27.0	Systematic Assessment	EG00012 affected782 at risk EG00113 affected806 at risk EG0024 affected403 at risk
Abdominal pain lower	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Abdominal pain upper	Gastrointestinal disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Ascites	Gastrointestinal disorders	27.0	Systematic Assessment	EG00015 affected782 at risk EG0019 affected806 at risk EG0026 affected403 at risk
Autoimmune colitis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Colitis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0006 affected782 at risk EG0010 affected806 at risk EG00211 affected403 at risk
Constipation	Gastrointestinal disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0013 affected806 at risk EG0022 affected403 at risk
Cyclic vomiting syndrome	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Diarrhoea	Gastrointestinal disorders	27.0	Systematic Assessment	EG00021 affected782 at risk EG00114 affected806 at risk EG00213 affected403 at risk
Diverticulum intestinal haemorrhagic	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Duodenal obstruction	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Duodenal perforation	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Dyspepsia	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Dysphagia	Gastrointestinal disorders	27.0	Systematic Assessment	EG00013 affected782 at risk EG00123 affected806 at risk EG0029 affected403 at risk
Enteritis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Enterocolitis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Gastric haemorrhage	Gastrointestinal disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG00111 affected806 at risk EG0024 affected403 at risk
Gastric perforation	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0013 affected806 at risk EG0021 affected403 at risk
Gastric stenosis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastric ulcer	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Gastritis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastrointestinal fistula	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Gastrointestinal haemorrhage	Gastrointestinal disorders	27.0	Systematic Assessment	EG00013 affected782 at risk EG0019 affected806 at risk EG0024 affected403 at risk
Gastrointestinal inflammation	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastrointestinal necrosis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastrointestinal obstruction	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Gastrointestinal perforation	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastrointestinal stenosis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Gastrooesophageal reflux disease	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Haematemesis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Haematochezia	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Haemoperitoneum	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Ileus	Gastrointestinal disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Ileus paralytic	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Immune-mediated enterocolitis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG00211 affected403 at risk
Impaired gastric emptying	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Intestinal haemorrhage	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Intestinal obstruction	Gastrointestinal disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0017 affected806 at risk EG0022 affected403 at risk
Intestinal perforation	Gastrointestinal disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Intestinal stenosis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Large intestinal haemorrhage	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Large intestinal stenosis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Large intestine perforation	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Lower gastrointestinal haemorrhage	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Malabsorption	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Malignant ascites	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Malignant gastrointestinal obstruction	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Melaena	Gastrointestinal disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Nausea	Gastrointestinal disorders	27.0	Systematic Assessment	EG0008 affected782 at risk EG00110 affected806 at risk EG0027 affected403 at risk
Obstruction gastric	Gastrointestinal disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0016 affected806 at risk EG0026 affected403 at risk
Obstructive pancreatitis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Oesophageal compression	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oesophageal fistula	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Oesophageal haemorrhage	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Oesophageal obstruction	Gastrointestinal disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0013 affected806 at risk EG0024 affected403 at risk
Oesophageal pain	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Oesophageal stenosis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Oesophageal ulcer haemorrhage	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oesophageal varices haemorrhage	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oesophagitis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pancreatitis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Pancreatitis acute	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Peritoneal adhesions	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Prepyloric stenosis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Proctitis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Retroperitoneal haematoma	Gastrointestinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Small intestinal obstruction	Gastrointestinal disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0015 affected806 at risk EG0020 affected403 at risk
Stomatitis	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Subileus	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Thrombosis mesenteric vessel	Gastrointestinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Upper gastrointestinal haemorrhage	Gastrointestinal disorders	27.0	Systematic Assessment	EG00017 affected782 at risk EG00110 affected806 at risk EG00213 affected403 at risk
Vomiting	Gastrointestinal disorders	27.0	Systematic Assessment	EG00029 affected782 at risk EG00123 affected806 at risk EG00211 affected403 at risk
Asthenia	General disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0015 affected806 at risk EG0023 affected403 at risk
Catheter site extravasation	General disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Catheter site haemorrhage	General disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Chest discomfort	General disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Complication associated with device	General disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Death	General disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Disease progression	General disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Effusion	General disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Face oedema	General disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Fatigue	General disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0012 affected806 at risk EG0026 affected403 at risk
Gait disturbance	General disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
General physical health deterioration	General disorders	27.0	Systematic Assessment	EG0005 affected782 at risk EG0017 affected806 at risk EG0023 affected403 at risk
Generalised oedema	General disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Inflammation	General disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Malaise	General disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0013 affected806 at risk EG0021 affected403 at risk
Mucosal inflammation	General disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Multiple organ dysfunction syndrome	General disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Non-cardiac chest pain	General disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oedema peripheral	General disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Pain	General disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0014 affected806 at risk EG0020 affected403 at risk
Performance status decreased	General disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Peripheral swelling	General disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pyrexia	General disorders	27.0	Systematic Assessment	EG00022 affected782 at risk EG00111 affected806 at risk EG0029 affected403 at risk
Sudden death	General disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0013 affected806 at risk EG0022 affected403 at risk
Systemic inflammatory response syndrome	General disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Ulcer haemorrhage	General disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Acute hepatic failure	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Autoimmune hepatitis	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0026 affected403 at risk
Bile duct stenosis	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Bile duct stone	Hepatobiliary disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Biliary cyst	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Biliary obstruction	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Cholangitis	Hepatobiliary disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cholangitis acute	Hepatobiliary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Cholecystitis	Hepatobiliary disorders	27.0	Systematic Assessment	EG0005 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Cholecystitis acute	Hepatobiliary disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Cholecystitis chronic	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cholestasis	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Drug-induced liver injury	Hepatobiliary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Hepatic cyst ruptured	Hepatobiliary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hepatic failure	Hepatobiliary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Hepatic function abnormal	Hepatobiliary disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0012 affected806 at risk EG0025 affected403 at risk
Hepatitis	Hepatobiliary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0025 affected403 at risk
Hepatitis acute	Hepatobiliary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hepatitis toxic	Hepatobiliary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hepatorenal failure	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Hepatotoxicity	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hyperbilirubinaemia	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hypertransaminasaemia	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Immune-mediated hepatic disorder	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Immune-mediated hepatitis	Hepatobiliary disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Jaundice	Hepatobiliary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Jaundice cholestatic	Hepatobiliary disorders	27.0	Systematic Assessment	EG0006 affected782 at risk EG0014 affected806 at risk EG0022 affected403 at risk
Liver disorder	Hepatobiliary disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Liver injury	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Portal hypertension	Hepatobiliary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Suspected drug-induced liver injury	Hepatobiliary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Anaphylactic reaction	Immune system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Contrast media allergy	Immune system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Drug hypersensitivity	Immune system disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Hypersensitivity	Immune system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Abdominal abscess	Infections and infestations	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Abdominal infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Abdominal sepsis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Amoebic colitis	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Anal abscess	Infections and infestations	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Appendicitis	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Appendicitis perforated	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Arthritis bacterial	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Bacteraemia	Infections and infestations	27.0	Systematic Assessment	EG0004 affected782 at risk EG0011 affected806 at risk EG0023 affected403 at risk
Biliary tract infection	Infections and infestations	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Bronchitis	Infections and infestations	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Bronchitis viral	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
COVID-19	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
COVID-19 pneumonia	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cellulitis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0013 affected806 at risk EG0022 affected403 at risk
Chorioretinitis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Clostridium difficile colitis	Infections and infestations	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Clostridium difficile infection	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Cystitis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Dengue fever	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Device related infection	Infections and infestations	27.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Device related sepsis	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Diarrhoea infectious	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Diverticulitis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Encephalitis	Infections and infestations	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Endocarditis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Endophthalmitis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Enteritis infectious	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Enterocolitis infectious	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Epididymitis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Febrile infection	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Giardiasis	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Haematological infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hepatitis C	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Herpes simplex reactivation	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Herpes virus infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Infection	Infections and infestations	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Influenza	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Intervertebral discitis	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Large intestine infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Localised infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Lower respiratory tract infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Lung abscess	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Lymphangitis	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Mycobacterium avium complex infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Neutropenic infection	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Neutropenic sepsis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Oesophageal candidiasis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Osteomyelitis	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Parainfluenzae virus infection	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Peritonitis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Peritonitis bacterial	Infections and infestations	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pneumonia	Infections and infestations	27.0	Systematic Assessment	EG00030 affected782 at risk EG00121 affected806 at risk EG00214 affected403 at risk
Pneumonia aspiration	Infections and infestations	27.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Pneumonia bacterial	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pneumonia klebsiella	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pneumonia pneumococcal	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pneumonia viral	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Psoas abscess	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pulmonary sepsis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pyelonephritis	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Respiratory tract infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Sepsis	Infections and infestations	27.0	Systematic Assessment	EG00012 affected782 at risk EG0018 affected806 at risk EG0023 affected403 at risk
Septic shock	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Sialoadenitis	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Skin infection	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Soft tissue infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Spontaneous bacterial peritonitis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Staphylococcal infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Stoma site infection	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Streptococcal bacteraemia	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Tonsillitis	Infections and infestations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Tuberculous pleurisy	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Upper respiratory tract infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Urinary tract infection	Infections and infestations	27.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0026 affected403 at risk
Urosepsis	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Vascular device infection	Infections and infestations	27.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Viral infection	Infections and infestations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Afferent loop syndrome	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Anastomotic stenosis	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Craniocerebral injury	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Fall	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0003 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Femoral neck fracture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Femur fracture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Fracture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gastroenteritis radiation	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Gastrointestinal stoma complication	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Heat stroke	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hip fracture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Humerus fracture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Infusion related reaction	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0006 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Lower limb fracture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Lumbar vertebral fracture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Overdose	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG00011 affected782 at risk EG0016 affected806 at risk EG0020 affected403 at risk
Post procedural haematoma	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Procedural complication	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Radius fracture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Road traffic accident	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Skin laceration	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Soft tissue injury	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Spinal compression fracture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Spinal fracture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Subdural haematoma	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Synovial rupture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Thoracic vertebral fracture	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Vascular access malfunction	Injury, poisoning and procedural complications	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Alanine aminotransferase increased	Investigations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Amylase increased	Investigations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Aspartate aminotransferase increased	Investigations	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Blood alkaline phosphatase increased	Investigations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Blood bilirubin increased	Investigations	27.0	Systematic Assessment	EG0006 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Blood corticotrophin decreased	Investigations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Blood creatinine increased	Investigations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Electrocardiogram ST segment elevation	Investigations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
General physical condition abnormal	Investigations	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Haemoglobin decreased	Investigations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hepatitis C virus test positive	Investigations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Lipase increased	Investigations	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Liver function test increased	Investigations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Neutrophil count decreased	Investigations	27.0	Systematic Assessment	EG0003 affected782 at risk EG0013 affected806 at risk EG0020 affected403 at risk
Platelet count decreased	Investigations	27.0	Systematic Assessment	EG0003 affected782 at risk EG0014 affected806 at risk EG0021 affected403 at risk
Transaminases increased	Investigations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Troponin increased	Investigations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Weight decreased	Investigations	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Decreased appetite	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0007 affected782 at risk EG0019 affected806 at risk EG0026 affected403 at risk
Dehydration	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0008 affected782 at risk EG0017 affected806 at risk EG0023 affected403 at risk
Diabetes mellitus	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Diabetes mellitus inadequate control	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Diabetic ketoacidosis	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Diabetic metabolic decompensation	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Electrolyte imbalance	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Failure to thrive	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Gout	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hypercalcaemia	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Hyperglycaemia	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Hyperkalaemia	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Hypernatraemia	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hypoalbuminaemia	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Hypoglycaemia	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Hypokalaemia	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0015 affected806 at risk EG0022 affected403 at risk
Hyponatraemia	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0011 affected806 at risk EG0023 affected403 at risk
Hypophagia	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Hypoproteinaemia	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Malnutrition	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Metabolic acidosis	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Type 1 diabetes mellitus	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Type 2 diabetes mellitus	Metabolism and nutrition disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Arthralgia	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Arthritis	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Back pain	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0004 affected782 at risk EG0014 affected806 at risk EG0021 affected403 at risk
Bone lesion	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Bone pain	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Fistula	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Intervertebral disc protrusion	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Mixed connective tissue disease	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Muscular weakness	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Musculoskeletal chest pain	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Myositis	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0023 affected403 at risk
Osteolysis	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pain in extremity	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Pathological fracture	Musculoskeletal and connective tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Basal cell carcinoma	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Cancer pain	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Gastric cancer	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Gastric neoplasm	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Laryngeal squamous cell carcinoma	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Malignant neoplasm progression	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG000248 affected782 at risk EG001246 affected806 at risk EG002112 affected403 at risk
Metastases to bone	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Metastases to central nervous system	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0003 affected782 at risk EG0014 affected806 at risk EG0020 affected403 at risk
Metastases to liver	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Metastases to meninges	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Metastasis	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Metastatic gastric cancer	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Myelodysplastic syndrome	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Neoplasm malignant	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Neoplasm progression	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Oesophageal adenocarcinoma	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oesophageal cancer metastatic	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Rectal cancer	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Second primary malignancy	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Squamous cell carcinoma	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Squamous cell carcinoma of lung	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Tumour associated fever	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Tumour haemorrhage	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Tumour necrosis	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Tumour obstruction	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Tumour pain	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Tumour ulceration	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Aphasia	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Brain oedema	Nervous system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Brain stem infarction	Nervous system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Central nervous system lesion	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cerebellar syndrome	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cerebral infarction	Nervous system disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Cerebral ischaemia	Nervous system disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Cerebrovascular accident	Nervous system disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Depressed level of consciousness	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Diabetic hyperosmolar coma	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Dizziness	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Embolic stroke	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Encephalitis autoimmune	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Encephalopathy	Nervous system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Epilepsy	Nervous system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Facial paresis	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Guillain-Barre syndrome	Nervous system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Headache	Nervous system disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Hemiparesis	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Hypokinesia	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Immune-mediated neuropathy	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Intracranial pressure increased	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Ischaemic stroke	Nervous system disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Metabolic encephalopathy	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Neuritis	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Neuropathy peripheral	Nervous system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Polyneuropathy	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Presyncope	Nervous system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Seizure	Nervous system disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Spinal cord compression	Nervous system disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Subarachnoid haemorrhage	Nervous system disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Syncope	Nervous system disorders	27.0	Systematic Assessment	EG0009 affected782 at risk EG0014 affected806 at risk EG0022 affected403 at risk
Transient ischaemic attack	Nervous system disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Device breakage	Product Issues	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Device dislocation	Product Issues	27.0	Systematic Assessment	EG0003 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Device leakage	Product Issues	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Device occlusion	Product Issues	27.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Stent malfunction	Product Issues	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Bipolar disorder	Psychiatric disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Depression	Psychiatric disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Eating disorder	Psychiatric disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Mental status changes	Psychiatric disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Suicide attempt	Psychiatric disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Acute kidney injury	Renal and urinary disorders	27.0	Systematic Assessment	EG0006 affected782 at risk EG0014 affected806 at risk EG0029 affected403 at risk
Cystitis noninfective	Renal and urinary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Dysuria	Renal and urinary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Haematuria	Renal and urinary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hydronephrosis	Renal and urinary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0021 affected403 at risk
Nephritis	Renal and urinary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Nephrolithiasis	Renal and urinary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Prerenal failure	Renal and urinary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Renal failure	Renal and urinary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0013 affected806 at risk EG0020 affected403 at risk
Renal impairment	Renal and urinary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Tubulointerstitial nephritis	Renal and urinary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Ureteric dilatation	Renal and urinary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Ureterolithiasis	Renal and urinary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Urinary retention	Renal and urinary disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0022 affected403 at risk
Urinary tract obstruction	Renal and urinary disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Benign prostatic hyperplasia	Reproductive system and breast disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Vaginal haemorrhage	Reproductive system and breast disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Acute respiratory failure	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Asphyxia	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Bronchospasm	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Chronic obstructive pulmonary disease	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0021 affected403 at risk
Cough	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Dyspnoea	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Haemothorax	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Hiccups	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Hypoxia	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Immune-mediated lung disease	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Interstitial lung disease	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0012 affected806 at risk EG0022 affected403 at risk
Laryngeal haemorrhage	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Malignant pleural effusion	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Mediastinal effusion	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Oropharyngeal discomfort	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pleural effusion	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0005 affected782 at risk EG0016 affected806 at risk EG0026 affected403 at risk
Pneumonitis	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG00019 affected782 at risk EG0011 affected806 at risk EG0027 affected403 at risk
Pneumonitis aspiration	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pneumothorax	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0003 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pulmonary artery thrombosis	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pulmonary embolism	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG00014 affected782 at risk EG00118 affected806 at risk EG00210 affected403 at risk
Pulmonary hypertension	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pulmonary oedema	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Respiratory failure	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0005 affected782 at risk EG0013 affected806 at risk EG0022 affected403 at risk
Restrictive pulmonary disease	Respiratory, thoracic and mediastinal disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Diabetic foot	Skin and subcutaneous tissue disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Drug eruption	Skin and subcutaneous tissue disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Eczema asteatotic	Skin and subcutaneous tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Ischaemic skin ulcer	Skin and subcutaneous tissue disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Pemphigoid	Skin and subcutaneous tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Rash	Skin and subcutaneous tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0023 affected403 at risk
Rash maculo-papular	Skin and subcutaneous tissue disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0010 affected806 at risk EG0022 affected403 at risk
Skin lesion	Skin and subcutaneous tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Toxic epidermal necrolysis	Skin and subcutaneous tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Urticaria	Skin and subcutaneous tissue disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Euthanasia	Surgical and medical procedures	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Axillary vein thrombosis	Vascular disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Capillary leak syndrome	Vascular disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0010 affected806 at risk EG0021 affected403 at risk
Circulatory collapse	Vascular disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Deep vein thrombosis	Vascular disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0013 affected806 at risk EG0023 affected403 at risk
Embolism	Vascular disorders	27.0	Systematic Assessment	EG0006 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Hypotension	Vascular disorders	27.0	Systematic Assessment	EG0002 affected782 at risk EG0012 affected806 at risk EG0020 affected403 at risk
Hypovolaemic shock	Vascular disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Jugular vein thrombosis	Vascular disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Obstructive shock	Vascular disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Pelvic venous thrombosis	Vascular disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Peripheral arterial occlusive disease	Vascular disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Peripheral artery occlusion	Vascular disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Peripheral ischaemia	Vascular disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Peripheral venous disease	Vascular disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Shock	Vascular disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Shock haemorrhagic	Vascular disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Subclavian artery stenosis	Vascular disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0010 affected806 at risk EG0020 affected403 at risk
Thrombosis	Vascular disorders	27.0	Systematic Assessment	EG0000 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk
Venous thrombosis	Vascular disorders	27.0	Systematic Assessment	EG0001 affected782 at risk EG0011 affected806 at risk EG0020 affected403 at risk

ID	Title	Description
BG000	Arm 1: Nivolumab + Chemotherapy (XELOX or FOLFOX)	Nivolumab + Xelox: Nivolumab 360 mg IV over 30 minutes on Day 1 of each treatment cycle, every 3 weeks + Oxaliplatin 130 mg/m2 IV on Day 1 of each treatment cycle + capecitabine 1000 mg/m2 orally twice daily (ie, 1000 mg/m2 in the morning and 1000 mg/m2 in the evening) on Days 1 to 14 of each treatment cycle, every 3 weeks Nivolumab + Folfox: Nivolumab 240 mg IV over 30 minutes on Day 1 of each treatment cycle, every 2 weeks + Oxaliplatin 85 mg/m2 + leucovorin 400 mg/m2 + fluorouracil 400 mg/m2 IV on Day 1 of each treatment cycle, and fluorouracil 1200 mg/m2 IV continuous infusion over 24 hours (or per local standard) daily on Days 1 and 2 of each treatment cycle, every 2 weeks
BG001	Arm 2: Chemotherapy (XELOX or FOLFOX)	Chemotherapy (XELOX or FOLFOX): Xelox: Oxaliplatin 130 mg/m2 IV on Day 1 of each treatment cycle + capecitabine 1000 mg/m2 orally twice daily (ie, 1000 mg/m2 in the morning and 1000 mg/m2 in the evening) on Days 1 to 14 of each treatment cycle, every 3 weeks. Folfox: Oxaliplatin 85 mg/m2 + leucovorin 400 mg/m2 + fluorouracil 400 mg/m2 IV on Day 1 of each treatment cycle, and fluorouracil 1200 mg/m2 IV continuous infusion over 24 hours (or per local standard) daily on Days 1 and 2 of each treatment cycle, every 2 weeks. This chemotherapy group consists of the two comparison chemotherapy sub-groups. Arm 2a (792 participants) is the comparison group to Arm 1 and Arm 2b (404 participants) is the comparison group to Arm 3. Some participants were counted in both Arm 2a and Arm 2b.
BG002	Arm 3: Nivolumab + Ipilimumab	1 mg/kg nivolumab administered IV over 30 minutes followed by ipilimumab 3 mg/kg administered IV over 30 minutes on Day 1 of each treatment cycle every 3 weeks for 4 doses (Cycles 1 to 4), followed by nivolumab 240 mg administered IV over 30 minutes on Day 1 of each treatment cycle every 2 weeks (Cycle 5 and beyond). Arm is closed to enrollment as of 05-June-2018.
BG003	Total	Total of all reporting groups

ID	Title	Description	Deaths (Affected)	Deaths (At Risk)	Serious Events (Affected)	Serious Events (At Risk)	Other Events (Affected)	Other Events (At Risk)
EG000	Nivo + Chemo	Nivolumab + Xelox: Nivolumab 360 mg IV over 30 minutes on Day 1 of each treatment cycle, every 3 weeks + Oxaliplatin 130 mg/m2 IV on Day 1 of each treatment cycle + capecitabine 1000 mg/m2 orally twice daily (ie, 1000 mg/m2 in the morning and 1000 mg/m2 in the evening) on Days 1 to 14 of each treatment cycle, every 3 weeks Nivolumab + Folfox: Nivolumab 240 mg IV over 30 minutes on Day 1 of each treatment cycle, every 2 weeks + Oxaliplatin 85 mg/m2 + leucovorin 400 mg/m2 + fluorouracil 400 mg/m2 IV on Day 1 of each treatment cycle, and fluorouracil 1200 mg/m2 IV continuous infusion over 24 hours (or per local standard) daily on Days 1 and 2 of each treatment cycle, every 2 weeks	691	782	529	782	763	782
EG001	Chemo	Chemotherapy (XELOX or FOLFOX): Xelox: Oxaliplatin 130 mg/m2 IV on Day 1 of each treatment cycle + capecitabine 1000 mg/m2 orally twice daily (ie, 1000 mg/m2 in the morning and 1000 mg/m2 in the evening) on Days 1 to 14 of each treatment cycle, every 3 weeks. Folfox: Oxaliplatin 85 mg/m2 + leucovorin 400 mg/m2 + fluorouracil 400 mg/m2 IV on Day 1 of each treatment cycle, and fluorouracil 1200 mg/m2 IV continuous infusion over 24 hours (or per local standard) daily on Days 1 and 2 of each treatment cycle, every 2 weeks. This chemotherapy group consists of the two comparison chemotherapy sub-groups. Arm 2a (792 participants) is the comparison group to Arm 1 and Arm 2b (404 participants) is the comparison group to Arm 3. Some participants were counted in both Arm 2a and Arm 2b.	741	806	474	806	756	806
EG002	Nivo + Ipi	1 mg/kg nivolumab administered IV over 30 minutes followed by ipilimumab 3 mg/kg administered IV over 30 minutes on Day 1 of each treatment cycle every 3 weeks for 4 doses (Cycles 1 to 4), followed by nivolumab 240 mg administered IV over 30 minutes on Day 1 of each treatment cycle every 2 weeks (Cycle 5 and beyond). Arm is closed to enrollment as of 05-June-2018.	361	403	307	403	369	403

ID	Term
D013274	Stomach Neoplasms
C562730	Adenocarcinoma Of Esophagus

ID	Term
D005770	Gastrointestinal Neoplasms
D004067	Digestive System Neoplasms
D009371	Neoplasms by Site
D009369	Neoplasms
D004066	Digestive System Diseases
D005767	Gastrointestinal Diseases
D013272	Stomach Diseases

ID	Term
D061067	Antibodies, Monoclonal, Humanized
D000911	Antibodies, Monoclonal
D000906	Antibodies
D007136	Immunoglobulins
D007162	Immunoproteins
D001798	Blood Proteins
D011506	Proteins
D000602	Amino Acids, Peptides, and Proteins
D012712	Serum Globulins
D005916	Globulins
D056831	Coordination Complexes
D009930	Organic Chemicals
D003841	Deoxycytidine
D003562	Cytidine
D011741	Pyrimidine Nucleosides
D011743	Pyrimidines
D006573	Heterocyclic Compounds, 1-Ring
D006571	Heterocyclic Compounds
D014498	Uracil
D011744	Pyrimidinones
D003853	Deoxyribonucleosides
D009705	Nucleosides
D009706	Nucleic Acids, Nucleotides, and Nucleosides
D005575	Formyltetrahydrofolates
D013763	Tetrahydrofolates
D005492	Folic Acid
D011622	Pterins
D011621	Pteridines
D006574	Heterocyclic Compounds, 2-Ring
D000072471	Heterocyclic Compounds, Fused-Ring
D003067	Coenzymes
D045762	Enzymes and Coenzymes

ID	Term
D000077594	Nivolumab
D000074324	Ipilimumab
D000077150	Oxaliplatin
D000069287	Capecitabine
D002955	Leucovorin
D005472	Fluorouracil