Predictive Value of Dynamic Combination of BNP and NGAL for the Prognosis of Patients With Sepsis

Predictive Value of Dynamic Combination of B-type Natriuretic Peptide and Neutrophil Gelatinase-associated Lipocalin for the Prognosis of Patients With Sepsis

Objective: to clarify the predictive value of brain natriuretic peptide (BNP) in combination with neutrophil gelatinase associated lipocalin (NGAL) for the prognosis of patients with sepsis.

Inclusion Criteria:

• age ≥18 years and <85 years;
• presence of severe sepsis according to Survival Sepsis Campaign 10;
• all patients voluntarily joined this study with informed consents.

Exclusion Criteria:

• participated in other trials within 30 days before the criteria for this trial were met;
• expected to die within 24 hours;
• pregnant;
• advanced malignancy with life expectancy <6 months;
• history of congestive heart failure;
• chronic renal dysfunction (baseline creatinine >176.8μmol/L); and
• relatives were unwilling to agree to the use of full life support.