Correlation Between PET and Advanced MRI in Multiple Sclerosis

Pilot Study of Positron Emission Tomography (PET) Imaging: Correlations With Advanced Magnetic Resonance Imaging in Multiple Sclerosis

Traditional Magnetic Resonance Imaging (MRI) in Multiple Sclerosis (MS) has enabled clinicians to measure disease activity but there are inherent limitations. Clinical/radiographic dissociation can be seen in some patients and the abnormalities are not specific.

This pilot study is an opportunity to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health.

Inclusion Criteria:

• Diagnosed with Multiple Sclerosis according to the 2011 McDonald criteria.
• Aged 18 to 60
• High or mixed affinity binder to rs6971 TSPO polymorphism

Exclusion Criteria:

• Pregnant or breastfeeding
• Suffering from an unstable medical condition
• Have a neurological or ocular disorder other than MS
• Any contra-indications to MRI