Here were present a controlled clinical trial comparing wire-guided lesion localization (WGLL)and radioguided occult lesion localization (ROLL) in patients treated for nonpalpable breast lesions at the Instituto Nacional de Cancerología (National Cancer Institute)in Bogotá,Colombia.

The aim of this study was to compare the radioguided occult lesion localization (ROLL) technique with the wire-guided lesion localization (WGLL) technique to assess the optimal localization and excision of nonpalpable breast lesions in patients at a unique reference medical center.

A controlled clinical trial was designed to compare the WGLL and ROLL techniques in women presenting with breast lesions diagnosed by mammography or ultrasound at the Instituto Nacional de Cancerología in Bogotá, Colombia from March 2006 to June 2011.

This study evaluate 129 patients; 64 (49.6%) patients were treated using ROLL and 65 (51.4%) using WGLL.

Inclusion Criteria:

• Female patients older than 18 years
• Lesions suggesting malignancy (BIRADS 4 and 5)
• Solid nodules in postmenopausal women (BIRADS 3 mammograms).

Exclusion Criteria:

• Pregnant or nursing
• Patients with suspected multifocal or multicentric disease (suspicious microcalcifications scattered over a wide area on mammography)
• Patients with retro-areola lesions (less than 2 cm away from the nipple)
• Lesions that had previously undergone surgery or excisional biopsies in the compromised breast