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The different subtypes of Schizophrenia might have a disordered connectivity as their final common pathways.
The investigators will use multimodal structural MRI to assess anatomical connectivity on the one side and its functional consequence on functional connectivity on the other side to assess two phenotypes of psychosis : periodic catatonia and cataphasia in comparison with control subjects.
The coherence between structural and functional anomalies will be especially studied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Schizophrenia |
| ||
| Normal controls. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Quantitative multiparametric and functional MRI | Other | Structural connectivity assessed in the cortex and the white matter using multimodal quantitative parametric imaging (R1, R2, R2*, DTI, susceptibility, macromolecular proton fraction, cortical thickness, VBM). Functional connectivity assessed using simple BOLD and combined ASL-BOLD sequences during multiple tasks including motor, language and working memory tasks. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in structural and functional connectivity according to the phenotype. Correlation between these changes | Statistical parametric mapping (SPM) will be applied on quantitative maps : rCBF (ml/100g/min), susceptibility (part per billion), R1, R2, R2* (all expressed in ms-1), fractional anisotropy (fraction), averaged diffusivity (μm²/sec), macromolecular proton fraction (percentage), cortical thickness (mm), VBM (probability of grey and white matter) and contrast maps (BOLD signal correlation with the anterior cingulate ROI). | Subjects will be assessed only once. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in rCBF and cognition according to the phenotype. Correlation between the different changes and the symptomatic scales. | Symptomatic scales : PANSS, SANS, SAPS, Calgary, Bush and Francis catatonia scale, the psychological experimental test operationalized for cataphasia, Clinician-rated dimension of psychosis symptom severity questionnaire assessing handedness, anhedonia, vigilance, QoL, activity, handicap, ruminations, depression and personality. Cognitive tests : grammar tests, semantic priming, implicit memory, CPT, fNART, Mill-Hill (part B) |
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Inclusion criteria (controls):
Additional inclusion criteria for patients:
Exclusion criteria:
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Schizophrenia patients (subdivided in periodic catatonia and cataphasia) and normal controls, both having the same procedure.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Psychiatrie, Hôpital Civil, Hôpitaux Universitaires de Strasbourg | Strasbourg | 67091 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29559372 | Derived | Foucher JR, Zhang YF, Roser M, Lamy J, De Sousa PL, Weibel S, Vidailhet P, Mainberger O, Berna F. A double dissociation between two psychotic phenotypes: Periodic catatonia and cataphasia. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Aug 30;86:363-369. doi: 10.1016/j.pnpbp.2018.03.008. Epub 2018 Mar 17. |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D002389 | Catatonia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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|
| Subjects will be assessed only once. |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |