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Although clinical presentation of influenza is often symptomatic, asymptomatic cases also occur. The knowledge of the incidence of asymptomatic influenza among healthcare workers is very important because of the risk of cross-transmission to hospitalized patients. The principal objective of the study is to estimate the incidence of symptomatic and asymptomatic influenza among healthcare workers in short-stay wards. The results of this study will lead to a better understanding of the burden of asymptomatic influenza among healthcare workers and might be used as an argument to increase influenza vaccine coverage among healthcare workers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Health-care workers | Experimental | Health-care workers recruited in the study will have blood sampling and naso-pharyngeal bottle-brush sampling |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling | Biological |
| ||
| Nasal swab |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of influenza cases | Incidence of asymptomatic and symptomatic influenza per 1000 days at risk among healthcare workers | 6 months after inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Fraction of asymptomatic influenza cases | Fraction of asymptomatic influenza cases among patients with confirmed influenza infection (seroconversion) | 6 months after inclusion |
| Stratified incidence ratios |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Edouard Herriot Hospital; Department of Epidemiology, Hygiene and Public Health | Lyon | 69437 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32750120 | Result | Benet T, Amour S, Valette M, Saadatian-Elahi M, Aho-Glele LS, Berthelot P, Denis MA, Grando J, Landelle C, Astruc K, Paris A, Pillet S, Lina B, Vanhems P; AFP Study Group. Incidence of Asymptomatic and Symptomatic Influenza Among Healthcare Workers: A Multicenter Prospective Cohort Study. Clin Infect Dis. 2021 May 4;72(9):e311-e318. doi: 10.1093/cid/ciaa1109. |
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| ID | Term |
|---|---|
| D007251 | Influenza, Human |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D009976 | Orthomyxoviridae Infections |
| D012327 | RNA Virus Infections |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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|
The objective is to compare the proportion of asymptomatic influenza among vaccinated and unvaccinated healthcare workers, stratified on the type of influenza virus , gender, age, and other covariates
| 6 months after inclusion |
| Incidence of influenza-like illness | The objective is to calculate the incidence of influenza-like illness without virological confirmation | 6 months after inclusion |
| proportion of health-care workers with Influenza vaccine coverage | The objective is to estimate the vaccination coverage against influenza among health care workers | 6 months after inclusion |
| Number of sick-leave days per participating ward | The objective is to estimate the professional impact of influenza in a population of healthcare workers | 6 months after inclusion |
| D014777 | Virus Diseases |
| D012140 | Respiratory Tract Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |