Interest of Serum Periostin Dosage in Patients With Bone Fibrous Dysplasia

Interest of Serum Periostin Dosage in Patients With Bone Fibrous Dysplasia

Fibrous dysplasia is a rare bone disease which can cause pain and fractures. It has been shown that periostin is over expressed in fibrous component in patients bones ; but periostin has never been measured out in serum of patients, although it is easy to assess. This study aims to show whether serum periostin is elevated in serum of patients with fibrous dysplasia, and if it is more elevated in patients with severe forms of the disease.

Inclusion Criteria:

• patients with fibrous dysplasia of the bone
• access to social security
• informed consent

Exclusion Criteria:

• no informed consent
• pregnancy
• patients with a history of conditions known to increase periostin serum (stade IV cancer, severe asthma, pulmonary fibrosis…)