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Fibrous dysplasia is a rare bone disease which can cause pain and fractures. It has been shown that periostin is over expressed in fibrous component in patients bones ; but periostin has never been measured out in serum of patients, although it is easy to assess. This study aims to show whether serum periostin is elevated in serum of patients with fibrous dysplasia, and if it is more elevated in patients with severe forms of the disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with bone fibrous dysplasia | Experimental | Patients with bone fibrous dysplasia will have a blood sampling to assess periostin rate in serum |
|
| Control subjects | No Intervention | Control subjects will have no intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling | Biological | Patients with bone fibrous dysplasia will have blood sampling to assess periostin rate in serum |
|
| Measure | Description | Time Frame |
|---|---|---|
| Periostin rate in serum | At inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Periostin rate in serum according to the number of fibrotic bones | At inclusion | |
| Periostin rate in serum in patients with severe phenotype of the disease | At inclusion | |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de rhumatologie Pavillon F - Hôpital Edouard Herriot | Lyon | 69437 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30616028 | Result | Guerin Lemaire H, Merle B, Borel O, Gensburger D, Chapurlat R. Serum periostin levels and severity of fibrous dysplasia of bone. Bone. 2019 Apr;121:68-71. doi: 10.1016/j.bone.2019.01.004. Epub 2019 Jan 4. |
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| ID | Term |
|---|---|
| D005357 | Fibrous Dysplasia of Bone |
| ID | Term |
|---|---|
| D010009 | Osteochondrodysplasias |
| D001848 | Bone Diseases, Developmental |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Periostin rate in serum in patients with Mac Cune Albright syndrome |
| At inclusion |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |