Myeloid Derived Suppressor Cells Control by Signal Regulatory Protein-alpha: Investigation in Hepatocellular Carcinoma

Myeloid Derived Suppressor Cells Control by SIRP-alpha: Investigation in Hepatocellular Carcinoma

project is to study and develop anti-Signal Regulatory Protein α (SIRPα) antibodies (Ab) as a new immunotherapy strategy in cancer.

Samples harvested from hepatocellular carcinoma (HCC) and ovarian cancer patients will be used in evaluation of the SIRP-CD47 expression and of the effect of the anti-human Signal Regulatory Protein (hSIRP) Ab on various cellular types from patients and healthy volunteers.

Inclusion Criteria:

• adult
• HCC patients (all BCLC stages accepted)
• patient consent for the use of their biological samples

Exclusion Criteria:

• patient with other cancers
• hepatitis C or B positive
• HCC treatment by chemo-embolization under 3 months
• under Sorafenib treatment within the month prior to collection
• underage or under guardianship patients