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| Name | Class |
|---|---|
| Institut National de la SantƩ Et de la Recherche MƩdicale, France | OTHER_GOV |
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project is to study and develop anti-Signal Regulatory Protein Ī± (SIRPĪ±) antibodies (Ab) as a new immunotherapy strategy in cancer.
Samples harvested from hepatocellular carcinoma (HCC) and ovarian cancer patients will be used in evaluation of the SIRP-CD47 expression and of the effect of the anti-human Signal Regulatory Protein (hSIRP) Ab on various cellular types from patients and healthy volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ascites | 30 inflammatory ascites of HCC patients (Collection of human samples ) Ascites will be selected only from HCC patients with an elevated protein level (ie inflammatory ascites) Puncture of ascites will be collected by paracentesis on HCC or ovarian cancer patients during their routine care These biological samples are affiliated with the biobank "hƩpato-gastroentƩrologie du CHU de Nantes" (declared under the reference DC-2011-1399). |
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| Resections | 30 HCC resections (Collection of human samples ) Fragment of resected HCC will be obtained after surgery and histological analysis will be performed by the anatomo-pathology service These biological samples are affiliated with the biobank "hƩpato-gastroentƩrologie du CHU de Nantes" (declared under the reference DC-2011-1399). |
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| blood samples | blood samples (Collection of human samples )will be collected prospectively for complementary functional analysis of peripheral These biological samples are affiliated with the biocollection "hƩpato-gastroentƩrologie du CHU de Nantes" (declared under the reference DC-2011-1399). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Collection of human samples | Procedure | Several types of samples will be used to test the effect of the drug candidate |
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| Measure | Description | Time Frame |
|---|---|---|
| evaluation of the SIRP/CD47 expression | samples harvested from HCC and ovarian cancer patients will be used in evaluation of the SIRP-CD47 expression and of the effect of the anti-hSIRP Ab on various cellular types from patients | baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Several types of samples will be used to test the effect of the drug candidate: 30 inflammatory ascites of HCC patients, 30 HCC resections (both from CHU de Nantes), 30 HCC patient blood samples.
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| Name | Affiliation | Role |
|---|---|---|
| Isabelle ARCHAMBEAUD, Dr | Nantes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nantes | Nantes | 44093 | France |
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| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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Blood and ascites will be analyzed for various cell populations by flow cytometry (different myeloid subsets including polymorphonuclear cells, MDSC and monocytes, T cell sub-populations including Tregs, CD8 and CD4 T cells, , B cells, and immature and mature NK cell). Myeloid infiltrate will be also evaluated by immunochemistry staining of CD68, CD163, CD206 and SIRPĪ± of HCCs from the tumour bank.
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |