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| Name | Class |
|---|---|
| Ministry of Science and ICT, Republic of Korea | OTHER_GOV |
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Necrotizing scleritis with severe ischemia is refractory to conventional treatment because of avascular necrosis.
The investigators assessed the therapeutic efficacy and safety of autologous perichondrium transplantation in patients with severe ischemic necrotizing scleritis, and analyzed the therapeutic effects.
Ischemic necrotizing scleritis patients who showed persistent and progressive scleral melting were included in this study.
Perichondrium tissue was harvested from the patient's ear cartilage and transplanted to reconstruct the scleral defect after the necrotic tissue removal.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Perichondrium | Experimental | Perichondrium Autografts |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Perichondrium Autografts | Procedure | Perichondrium tissue was harvested from the patient's ear cartilage and transplanted to reconstruct the scleral defect. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Success Rate of Repair of Scleral Defects | Success Rate of Repair of Scleral Defects | Six months after reconstructive surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Post-Operative Complications | Six months after reconstructive surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jae Chan Kim, Ph.D. | Chung-Ang University Hospital | Principal Investigator |
| Jee Taek Kim, Ph.D. | Chung-Ang University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chung Ang University Hospital | Seoul | 156-755 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 5650814 | Background | Watson PG, Hayreh SS, Awdry PN. Episcleritis and scleritis. I. Br J Ophthalmol. 1968 Mar;52(3):278-9 contd. doi: 10.1136/bjo.52.3.278. No abstract available. | |
| 2299561 | Background | Mamalis N, Johnson MD, Haines JM, Teske MP, Olson RJ. Corneal-scleral melt in association with cataract surgery and intraocular lenses: a report of four cases. J Cataract Refract Surg. 1990 Jan;16(1):108-15. doi: 10.1016/s0886-3350(13)80884-x. |
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| ID | Term |
|---|---|
| D015423 | Scleritis |
| ID | Term |
|---|---|
| D015422 | Scleral Diseases |
| D005128 | Eye Diseases |
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|
| 7724185 | Background | Sainz de la Maza M, Foster CS, Jabbur NS. Scleritis associated with systemic vasculitic diseases. Ophthalmology. 1995 Apr;102(4):687-92. doi: 10.1016/s0161-6420(95)30970-0. |
| 5729586 | Background | Torchia RT, Dunn RE, Pease PJ. Fascia lata grafting in scleromalacia perforans with lamellar corneal-scleral dissection. Am J Ophthalmol. 1968 Oct;66(4):705-9. doi: 10.1016/0002-9394(68)91293-2. No abstract available. |
| 18717447 | Background | Yalcindag FN, Celik S, Ozdemir O. Repair of anterior staphyloma with dehydrated dura mater patch graft. Ophthalmic Surg Lasers Imaging. 2008 Jul-Aug;39(4):346-7. doi: 10.3928/15428877-20080701-19. |
| 921583 | Background | Breslin CW, Katz JI, Kaufman HE. Surgical management of necrotizing scleritis. Arch Ophthalmol. 1977 Nov;95(11):2038-40. doi: 10.1001/archopht.1977.04450110132017. |
| 6672701 | Background | Koenig SB, Kaufman HE. The treatment of necrotizing scleritis with an autogenous periosteal graft. Ophthalmic Surg. 1983 Dec;14(12):1029-32. |
| 11917176 | Background | Ma DH, Wang SF, Su WY, Tsai RJ. Amniotic membrane graft for the management of scleral melting and corneal perforation in recalcitrant infectious scleral and corneoscleral ulcers. Cornea. 2002 Apr;21(3):275-83. doi: 10.1097/00003226-200204000-00008. |
| 2710520 | Background | Sainz de la Maza M, Tauber J, Foster CS. Scleral grafting for necrotizing scleritis. Ophthalmology. 1989 Mar;96(3):306-10. doi: 10.1016/s0161-6420(89)32892-2. |
| 18235911 | Background | Araf D, Moura Eda M, Rodrigues CJ, Figueiredo LA. [Homologous scleral and dura mater grafts in rabbit eyes: a comparative histopathological analysis]. Arq Bras Oftalmol. 2007 Nov-Dec;70(6):981-7. doi: 10.1590/s0004-27492007000600018. Portuguese. |
| 8841312 | Background | Beaver HA, Patrinely JR, Holds JB, Soper MP. Periocular autografts in socket reconstruction. Ophthalmology. 1996 Sep;103(9):1498-502. doi: 10.1016/s0161-6420(96)30477-6. |
| 8760859 | Background | Bairati A, Comazzi M, Gioria M. A comparative study of perichondrial tissue in mammalian cartilages. Tissue Cell. 1996 Aug;28(4):455-68. doi: 10.1016/s0040-8166(96)80031-0. |
| 16625212 | Background | Togo T, Utani A, Naitoh M, Ohta M, Tsuji Y, Morikawa N, Nakamura M, Suzuki S. Identification of cartilage progenitor cells in the adult ear perichondrium: utilization for cartilage reconstruction. Lab Invest. 2006 May;86(5):445-57. doi: 10.1038/labinvest.3700409. |
| 18216576 | Background | Casas VE, Kheirkhah A, Blanco G, Tseng SC. Surgical approach for scleral ischemia and melt. Cornea. 2008 Feb;27(2):196-201. doi: 10.1097/ICO.0b013e31815ba1ae. |
| 19002264 | Background | Seko Y, Azuma N, Takahashi Y, Makino H, Morito T, Muneta T, Matsumoto K, Saito H, Sekiya I, Umezawa A. Human sclera maintains common characteristics with cartilage throughout evolution. PLoS One. 2008;3(11):e3709. doi: 10.1371/journal.pone.0003709. Epub 2008 Nov 12. |
| 16496288 | Background | Franz-Odendaal TA, Vickaryous MK. Skeletal elements in the vertebrate eye and adnexa: morphological and developmental perspectives. Dev Dyn. 2006 May;235(5):1244-55. doi: 10.1002/dvdy.20718. |
| 24817999 | Background | Koob TJ, Lim JJ, Massee M, Zabek N, Rennert R, Gurtner G, Li WW. Angiogenic properties of dehydrated human amnion/chorion allografts: therapeutic potential for soft tissue repair and regeneration. Vasc Cell. 2014 May 1;6:10. doi: 10.1186/2045-824X-6-10. eCollection 2014. |
| 17396107 | Background | Smith JR, Mackensen F, Rosenbaum JT. Therapy insight: scleritis and its relationship to systemic autoimmune disease. Nat Clin Pract Rheumatol. 2007 Apr;3(4):219-26. doi: 10.1038/ncprheum0454. |
| 20061978 | Background | Boccieri A, Marianetti TM. Perichondrium graft: harvesting and indications in nasal surgery. J Craniofac Surg. 2010 Jan;21(1):40-4. doi: 10.1097/SCS.0b013e3181c362df. |