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This study will evaluate the impact of regular use of cannabis on the spatial sensitivity of magnocellular system (visual event-related potential, visual ERP).
Secondary purposes of this study are to evaluate the impact of regular use of cannabis on the temporal sensitivity of magnocellular system (visual event-related potential), on the dynamics of cortical visual processing during face perception test (visual event-related potential) and on functioning of retinal photopic and scotopic systems (electroretinogram).
The ancillary study is a genetic analysis of a group of candidate genes that aims to identify biomarkers for changes in visual processing. This will allow to distinguish among more homogeneous and specific groups in future studies on larger cannabis user population. This ancillary study concerns all participants subject to their informed consent (facultative study).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cannabis users | Other |
| |
| Healthy volunteers, not cannabis/tobacco users | Other |
| |
| Healthy volunteers, tobacco users | Other |
| |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Electroretinography | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Amplitude of P100 wave in contrast sensibility test | up to 1 month | |
| Culmination time of the P100 wave in contrast sensibility test | up to 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Amplitude of P100 wave in visual simultaneity test | up to 1 month | |
| Culmination time of P100 wave in visual simultaneity test | up to 1 month | |
| Amplitude of P100 wave in face perception test |
| Measure | Description | Time Frame |
|---|---|---|
| Relationship between variants of candidate genes for alterations of visual treatment and amplitude of P100 wave in contrast sensibility test | up to 3 years |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Vincent LAPREVOTE | Maison des Addictions - CHU de Nancy, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maison des Addictions - CHU de Nancy, Hôpital St Julien | Nancy | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37208126 | Derived | Remy I, Bernardin F, Ligier F, Krieg J, Maillard L, Schwan R, Schwitzer T, Laprevote V. Association between retinal and cortical visual electrophysiological impairments in schizophrenia. J Psychiatry Neurosci. 2023 May 19;48(3):E171-E178. doi: 10.1503/jpn.220224. Print 2023 May-Jun. | |
| 34891077 | Derived | Bernardin F, Schwitzer T, Schwan R, Angioi-Duprez K, Ligier F, Bourion-Bedes S, Jansen C, Giersch A, Laprevote V. Altered central vision and amacrine cells dysfunction as marker of hypodopaminergic activity in treated patients with schizophrenia. Schizophr Res. 2022 Jan;239:134-141. doi: 10.1016/j.schres.2021.11.049. Epub 2021 Dec 7. |
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| Schizophrenia patients |
| Other |
|
| Contrast sensitivity test during Electroencephalography | Other | Stimuli are black and white grids, having different range of spatial frequencies, presented with different contrasts on a grey background thanks to a computer monitor, in a dark room. Participants are requested to maintain central fixation. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes. |
|
| Visual simultaneity test during Electroencephalography | Other | Two vertical bars are showed on a monitor, on the link and right of point of central fixation. Bars appear simultaneously or with a 10 to 200 ms asynchrony. Participants must determine whether stimuli are simultaneous or asynchronous and answer pressing the link button for simultaneity or right button for asynchrony. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes. |
|
| Face perception test during Electroencephalography | Other | Faces filtered in different spatial frequence ranges are showed randomly on a monitor, in a dark room. Participants must maintain a central fixation thank to a fixation cross. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes. |
|
| CAST (cannabis abuse screening test) | Other |
|
| PANSS (Positive And Negative Symptoms Scale) test | Other |
|
| Delayed Matching to Sample (DMS) test | Other |
|
| Spatial Working Memory (SWM) test | Other |
|
| Rapid Visual Information Processing (RVP) test | Other |
|
| Test for attentional performance (TAP) / Divided Attention | Other |
|
| Collection of saliva sample | Other | In case of specific consent of participant to ancillary study, for ancillary study |
|
| up to 1 month |
| Amplitude of N170 wave in face perception test | up to 1 month |
| Culmination time of P100 wave in face perception test | up to 1 month |
| Culmination time of N170 wave in face perception test | up to 1 month |
| Amplitude of "a" wave in different ERG sequences | day 0 |
| Amplitude of "b" wave in different ERG sequences | day 0 |
| Culmination time of "a" wave in different ERG sequences | day 0 |
| Culmination time of "b" wave in different ERG sequences | day 0 |
| 34520807 | Derived | Remy I, Schwitzer T, Albuisson E, Schwan R, Krieg J, Bernardin F, Ligier F, Lalanne L, Maillard L, Laprevote V. Impaired P100 among regular cannabis users in response to magnocellular biased visual stimuli. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110437. doi: 10.1016/j.pnpbp.2021.110437. Epub 2021 Sep 11. |
| ID | Term |
|---|---|
| D002189 | Marijuana Abuse |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D015870 | Gene Expression |
| D004113 | Succimer |
| ID | Term |
|---|---|
| D055614 | Genetic Phenomena |
| D013386 | Succinates |
| D003998 | Dicarboxylic Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D013438 | Sulfhydryl Compounds |
| D013457 | Sulfur Compounds |
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