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The aim of this observational study is to create a data base to extract feature of fast-acting drugs that can be monitor in real time to design control strategies based on high order sliding mode controller to create a robust drug infusion system.
The aim of this observational study is to create a database to extract feature of fast-acting drugs that can be monitor in real time to design control strategies based on high order sliding mode controller to create a robust drug infusion system.
The observed drugs in this study are fast acting insulin, propofol and sodium nitroprusside.
The effect of insulin will be measured by a continuous glucose monitor, the effect of propofol by a bispectral index monitor and the the effect of sodium nitroprusside by a invasive blood pressure monitor.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Glucose monitoring | Glucose will be monitor in patients using fast-acting insulin. | ||
| Depth of anesthesia monitoring | Depth of anesthesia will be monitor in patients undergoing cardiac surgery. | ||
| Blood pressure monitoring | Invasive blood pressure will be monitor in patients undergoing cardiac surgery. |
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| Measure | Description | Time Frame |
|---|---|---|
| Glucose | The glucose will be measured by a continuous glucose monitor. For the group of patients for diabetes. Note: This protocol has three primary outputs because its objective is to create a database of each output to analyze the response to the associated drug (insulin, propofol and sodium nitroprusside. | Every 5 minutes during 3 days. |
| Bispectral Index | Depth of anesthesia will be measured by a Bispectral Index monitor. | Every second during surgery |
| Invasive blood pressure | Every 5 minutes during surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Patients scheduled for surgery in the Cardiology Hospital CMNSXXI or treated with fast-acting insulin in the Cardiology Hospital CMNSXXI
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| Name | Affiliation | Role |
|---|---|---|
| Ana Gallardo, Dr | Investigator | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Unidad de Investigación Médica en Enfermedades Metabólicas IMSS | Mexico City | Mexico City | 06720 | Mexico |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |