Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty

Patient Outcomes With Periarticular Liposomal Bupivacaine Injection vs Adductor Canal Block After Primary Total Knee Arthroplasty

This study is being done to evaluate the outcomes of patients undergoing total knee replacement with two different methods of local pain control:shots of liposomal bupivacaine, a long acting anesthetic, directly into the knee during surgery or anesthetic delivered continuously to the adductor canal to provide long term pain relief. The goal is to try to find a standard protocol that provides the greatest pain relief for patients undergoing total knee replacement.

Inclusion Criteria:

• Male or non-pregnant female between the ages of 18-65
• Patients willing and able to sign the informed consent
• Patients able to comply with follow-up requirements including self-evaluations
• Patients requiring a primary total knee replacement
• Patients with a diagnosis of osteoarthritis, traumatic arthritis, or avascular necrosis

Exclusion Criteria:

• Revision total knee arthroplasty
• Bilateral total knee arthroplasty
• Patients with inflammatory arthritis
• Patients with a body mass index (BMI) > 40
• Allergy to ropivacaine, bupivacaine, or other local anesthetic agents
• Current use of opioid drugs
• Patients with a history of total or unicompartmental reconstruction of the affected joint
• Patients that have had a high tibial osteotomy or femoral osteotomy
• Patients with neuromuscular or neurosensory deficiency, which would limit the ability to assess pain levels
• Patients with a systemic or metabolic disorder leading to progressive bone deterioration
• Patients that are immunologically compromised, or receiving chronic steroids (>30 days), excluding inhalers
• Patients' bone stock is compromised by disease or infection, which cannot provide adequate support and/or fixation to the prosthesis
• Patients with knee fusion to the affected joint
• Patients with an active or suspected latent infection in or about the knee joint
• Patients that are prisoners