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| Name | Class |
|---|---|
| Grupo de Estudios Clínicos Oncológicos Peruano | OTHER |
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To evaluate the attitude of pre menopausal women with breast cancer faced with the risk of loss of fertility caused by chemotherapy using EORTC's Fertility Questionnaire.
To characterize the attitude of pre menopausal patients with breast cancer regarding the risks of infertility based on the following variables:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pre menopausal women with breast cancer | Pre menopausal women with breast cancer prior treatment in face of infertility evoked by chemotherapy |
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| Measure | Description | Time Frame |
|---|---|---|
| To analyze the number of pre-menopausal patients diagnosed with breast cancer that did not agree in receiving chemotherapy due to the risk of infertility | Baseline and 1 year after after the first interview |
| Measure | Description | Time Frame |
|---|---|---|
| Infertility risk for breast cancer patients after accepting chemotherapy | Baseline and 1 year after the first interview | |
| Minimal percentage of cure necessary for patients accept the chemotherapy treatment | Baseline and 1 year after the first interview |
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Inclusion Criteria:
Exclusion Criteria:
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Pre menopausal women diagnosed with breast cancer prior treatment
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| Name | Affiliation | Role |
|---|---|---|
| Gustavo Werutsky, MD | Latin American Cooperative Oncology Group | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CPO - Pucrs | Porto Alegre | Rio Grande do Sul | Brazil | |||
| HCPA |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20610543 | Background | Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300. doi: 10.3322/caac.20073. Epub 2010 Jul 7. | |
| 19394537 | Background | Benson JR, Jatoi I, Keisch M, Esteva FJ, Makris A, Jordan VC. Early breast cancer. Lancet. 2009 Apr 25;373(9673):1463-79. doi: 10.1016/S0140-6736(09)60316-0. |
| Label | URL |
|---|---|
| Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 10 \[Internet\]. Lyon, France: International Agency for Research on Cancer; 2010 | View source |
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| Age when diagnosed | Baseline and 1 year after the first interview |
| Number of children | Baseline and 1 year after the first interview |
| Desire to have kids | Baseline and 1 year after the first interview |
| Marital status | Baseline |
| Scholarity | Baseline |
| Period of time since the diagnosis | Baseline |
| Chemotherapy scheme administration | Baseline and 1 year after the first interview |
| Period of time from the last menstruation period | Baseline and 1 year after the first interview |
| Description of quality of life of patients with the EORTC QLQ-BR23 | Baseline and 1 year after the first interview |
| Porto Alegre |
| Rio Grande do Sul |
| Brazil |
| Hospital Pérola Byington | São Paulo | Brazil |
| Instituto Nacional de Oncologia y Radiobiologia | Havana | Cuba |
| Cenro Oncologico Estatal ISSEMYM | Toluca | Mexico |
| INEN | Surquillo | Peru |
| Hospital de Clínicas San Agustín | Puerto Cabello | Venezuela |
| 23116682 | Background | Cardoso F, Loibl S, Pagani O, Graziottin A, Panizza P, Martincich L, Gentilini O, Peccatori F, Fourquet A, Delaloge S, Marotti L, Penault-Llorca F, Kotti-Kitromilidou AM, Rodger A, Harbeck N; European Society of Breast Cancer Specialists. The European Society of Breast Cancer Specialists recommendations for the management of young women with breast cancer. Eur J Cancer. 2012 Dec;48(18):3355-77. doi: 10.1016/j.ejca.2012.10.004. Epub 2012 Oct 29. |
| 11886005 | Background | Colleoni M, Rotmensz N, Robertson C, Orlando L, Viale G, Renne G, Luini A, Veronesi P, Intra M, Orecchia R, Catalano G, Galimberti V, Nole F, Martinelli G, Goldhirsch A. Very young women (<35 years) with operable breast cancer: features of disease at presentation. Ann Oncol. 2002 Feb;13(2):273-9. doi: 10.1093/annonc/mdf039. |
| Background | Vallejos Sologuren C, Gómez HL, et al. Clinicopathologic and outcome variables of worse prognosis in premenopausal patients (pts) age 35 and younger. 2010 Breast Cancer Symposium. Abstract 65 |
| 7999454 | Background | Reichman BS, Green KB. Breast cancer in young women: effect of chemotherapy on ovarian function, fertility, and birth defects. J Natl Cancer Inst Monogr. 1994;(16):125-9. |
| 24038775 | Background | Senkus E, Gomez H, Dirix L, Jerusalem G, Murray E, Van Tienhoven G, Westenberg AH, Bottomley A, Rapion J, Bogaerts J, Di Leo A, Neskovic-Konstantinovic Z. Attitudes of young patients with breast cancer toward fertility loss related to adjuvant systemic therapies. EORTC study 10002 BIG 3-98. Psychooncology. 2014 Feb;23(2):173-82. doi: 10.1002/pon.3384. Epub 2013 Aug 29. |
| 2678491 | Background | Gradishar WJ, Schilsky RL. Ovarian function following radiation and chemotherapy for cancer. Semin Oncol. 1989 Oct;16(5):425-36. No abstract available. |
| 17036039 | Background | Stearns V, Schneider B, Henry NL, Hayes DF, Flockhart DA. Breast cancer treatment and ovarian failure: risk factors and emerging genetic determinants. Nat Rev Cancer. 2006 Nov;6(11):886-93. doi: 10.1038/nrc1992. Epub 2006 Oct 12. |
| 6687378 | Background | Dnistrian AM, Schwartz MK, Fracchia AA, Kaufman RJ, Hakes TB, Currie VE. Endocrine consequences of CMF adjuvant therapy in premenopausal and postmenopausal breast cancer patients. Cancer. 1983 Mar 1;51(5):803-7. doi: 10.1002/1097-0142(19830301)51:53.0.co;2-v. |
| Background | Moore HCF, et al. Phase III trial (Prevention of Early Menopause Study [POEMS]-SWOG S0230) of LHRH analog during chemotherapy (CT) to reduce ovarian failure in earlystage, hormone receptor-negative breast cancer: An international Intergroup trial of SWOG, IBCSG, ECOG, and CALGB (Alliance). J Clin Oncol 32:5s, 2014 (suppl; abstr LBA505) |
| 14512398 | Background | Brandberg Y, Michelson H, Nilsson B, Bolund C, Erikstein B, Hietanen P, Kaasa S, Nilsson J, Wiklund T, Wilking N, Bergh J; Scandinavian Breast Group Study 9401. Quality of life in women with breast cancer during the first year after random assignment to adjuvant treatment with marrow-supported high-dose chemotherapy with cyclophosphamide, thiotepa, and carboplatin or tailored therapy with Fluorouracil, epirubicin, and cyclophosphamide: Scandinavian Breast Group Study 9401. J Clin Oncol. 2003 Oct 1;21(19):3659-64. doi: 10.1200/JCO.2003.07.020. |
| 41049579 | Derived | Werutsky G, Villarreal-Garza C, Gomez HL, Campos-Gomez S, Reyes RO, Liedke PER, Reinert T, Dybal V, Martinez-Mesa J, Nunes Filho PR, de Jesus RG, Zaffaroni F, Garcia VS, Seibel MF, Barrios P, Rocha MS, Barrios CH. Factors associated with accepting chemotherapy despite the risk of fertility loss in Latin American breast cancer patients-LACOG 0414 study. Ther Adv Med Oncol. 2025 Oct 2;17:17588359251378946. doi: 10.1177/17588359251378946. eCollection 2025. |
| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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