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| Name | Class |
|---|---|
| Ecole des hautes études d'ingénieur (HEI) | UNKNOWN |
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The hypothesis of this study is that progressive AIS is characterized by a disorder of orthostatic postural control. The analysis and the treatment of posturographic signal on computerized integrate force plates, coupled to clinical and radiographic examinations, could highlight predictive and reliable factors at the moment of diagnosis. Thus, it could help the clinician in his therapeutic approach, based on the postural control improvement (individualized prescription in kinesitherapy, better adaptation to orthopedic treatments by corset). This method is non-invasive, without side effects, fast and achievable in routine care at the moment of the diagnosis of AIS.
Adolescent idiopathic scoliosis (AIS) is a tridimensional spine deformation affecting 2% of subjects between 10 and 16 years-old being predominant among girls. It is a severe, progressive and multifactorial disease, and a genetic origin is currently admitted.
AIS is progressive (in 3 out of 10 cases) when the scoliosis radiographic frontal angle (Cobb angle) strictly increases by 5° between the diagnosis date and the end of growth. This progression can be severe requiring heavy treatments (corset, surgery) and it can generate adverse effects (spine pain, cardio-respiratory and functional consequences on walking). The lack of reliable criteria to predict the evolution of AIS is a real problem for the therapeutic decision and it can impact the socio-economic cost of the disease.
Several studies show orthostatic postural control anomalies in AIS. The orthostatic postural control is elaborated from the central integration of different sensorial signals (visual, somesthesic and vestibular).
Posturography, on computerized integrate force plates, allows to quantify sensorial components of orthostatic postural control. This technique can confirm the disorders of orthostatic postural control in AIS, but the parameters used can not evaluate with precision the progressive potential.
The posturographic signal analysis could lead to the implementation of therapeutic strategies adapted to progressive risk. Moreover, this method could prevent the progression in major scoliosis, limit the use of radiography, the application of a constraining corset (worn 23 hours a day) and the possibility of heavy surgery (extent arthrodesis).
The hypothesis of this study is that progressive AIS is characterized by a disorder of orthostatic postural control. The analysis and the treatment of posturographic signal on computerized integrate force plates, coupled to clinical and radiographic examinations, could highlight predictive and reliable factors at the moment of diagnosis. Thus, it could help the clinician in his therapeutic approach, based on the postural control improvement (individualized prescription in kinesitherapy, better adaptation to orthopedic treatments by corset). This method is non-invasive, without side effects, fast and achievable in routine care at the moment of the diagnosis of AIS.
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| Measure | Description | Time Frame |
|---|---|---|
| Measure of the evolution of AIS by Recurrence quantification analysis (RQA) | This parameter allows a posturographic recording of the patient in order to predict the evolution of the disease | Change from baseline at 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Questionnaire to determine presence or absence of family background | For statistical analysis categorical variables may be assigned with numeric indices | Change from baseline at 24 months |
| Questionnaire to determine presence or absence of concomitant illnesses |
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Inclusion Criteria:
Exclusion Criteria:
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Female subjects from 11 to 14 years with AIS
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| Name | Affiliation | Role |
|---|---|---|
| Catanzariti Jean-François, MD | Lille Catholic University | Principal Investigator |
| Olivier Agnani | Lille Catholic University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondation Hopale | Berck | Hauts-de-France | 62600 | France | ||
| Centre de MPR pour enfants de Bois Larris |
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| ID | Term |
|---|---|
| D012600 | Scoliosis |
| ID | Term |
|---|---|
| D013121 | Spinal Curvatures |
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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For statistical analysis categorical variables may be assigned with numeric indices |
| Change from baseline at 24 months |
| Questionnaire to determine presence or absence of clinical tests of equilibration | For statistical analysis categorical variables may be assigned with numeric indices | Change from baseline at 24 months |
| Questionnaire to determine presence or absence of susceptibility to sensorial conflicts | For statistical analysis categorical variables may be assigned with numeric indices | Change from baseline at 24 months |
| Questionnaire to determine presence or absence of visio-manual laterality | For statistical analysis categorical variables may be assigned with numeric indices | Change from baseline at 24 months |
| Questionnaire to determine type of scoliosis | For statistical analysis categorical variables may be assigned with numeric indices | Change from baseline at 24 months |
| Questionnaire to determine presence or absence of deformed body perception | For statistical analysis categorical variables may be assigned with numeric indices | Change from baseline at 24 months |
| Questionnaire to determine date of first periods | Questionnaire to determine date of first periods | Change from baseline at 24 months |
| Quantification of body mass index | Quantification of body mass index | Change from baseline at 24 months |
| Questionnaire to determine presence or absence of socio-demographic variables | For statistical analysis categorical variables may be assigned with numeric indices | at baseline |
| Fukuda stepping test in order to evaluate the vestibular sensory input | The purpose of the Fukuda Stepping Test (FST) is to measure asymmetrical vestibulospinal reflex tone resulting from labyrinthine dysfunction | Change from baseline at 24 months |
| Pearson correlation coefficient to determine the correlation between posturographic and radiographic parameters | Pearson correlation coefficient to determine the correlation between posturographic and radiographic parameters | Change from baseline at 24 months |
| Score of the motion Sickness Susceptibility Questionnaire | Score of the motion Sickness Susceptibility Questionnaire | Change from baseline at 24 months |
| Trunk Appearance Perception Scale | Evaluation of self appearance or image | Change from baseline at 24 months |
| Lamorlaye |
| Hauts-de-France |
| 60260 |
| France |
| SSR pédiatrique Marc Sautelet | Villeneuve-d'Ascq | Hauts-de-France | 59650 | France |
| CHU d'Amiens | Amiens | Picardie | 80054 | France |