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Prospective monocentric double-blind controlled randomised trial Aim is to assess prolonged postsurgical analgesia by intravenous dexamethasone versus intravenous placebo, after ultrasound guided axillary brachial plexus block
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intravenous dexamethasone | Active Comparator | intravenous injection of 8mg (2ml) of dexamethasone during regional anesthesia |
|
| intravenous placebo | Placebo Comparator | intravenous injection of 2ml of NaCl 0.9% during regional anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intravenous dexamethasone | Drug | intravenous injection of dexamethasone |
|
| Measure | Description | Time Frame |
|---|---|---|
| Analgesia duration after axillary brachial plexus block | time to first pain at surgical site, an average of 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Motor block duration after axillary brachial plexus block Safety | up to block recovery, an average of 24 hours | |
| Sensory block duration after axillary brachial plexus block | up to block recovery, an average of 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU de Besancon | Besançon | 25000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30777900 | Derived | Clement JC, Besch G, Puyraveau M, Grelet T, Ferreira D, Vettoretti L, Pili-Floury S, Samain E, Berthier F. Clinical effectiveness of single dose of intravenous dexamethasone on the duration of ropivacaine axillary brachial plexus block: the randomized placebo-controlled ADEXA trial. Reg Anesth Pain Med. 2019 Mar;44(3):e100035. doi: 10.1136/rapm-2018-100035. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D005543 | Forearm Injuries |
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| intravenous placebo | Drug | intravenous injection of placebo |
|
| perineural ropivacaine | Drug | brachial plexus block with perineural injection of Ropivacaine in the axillary fossa |
|
| ultrasound guidance | Other | ultrasound guidance for brachial plexus block in the axillary fossa |
|
| incidence of adverse event | 6 month |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D001134 | Arm Injuries |
| D014947 | Wounds and Injuries |
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009422 | Nervous System Diseases |