In the VERROUREA study, there were two cases of an abnormal increase in TCA. In theory no leakage of the lock into the bloodstream should have been seen. Lock leakage could have particularly serious, and especially clinical, repercussions in these patients who already have a high risk of haemorrhage given the numerous associated comorbidities. The aim of this study is to investigate the leakage of locks into the bloodstream by measuring, before and after injection of the lock, the evolution of haemostasis tests and calcaemia. The findings will complete safety data already collected in the VERROU REA study.

Inclusion Criteria:

• Patient aged > 18 years
• Requiring dialysis for acute kidney failure
• In whom a first non-tunnelled catheter has been inserted
• In the jugular or femoral position
• Once informed consent has been obtained from the patient, a family member or a person of trust

Exclusion Criteria:

• Patients with active and poorly-controlled bleeding
• Known allergy to citrate
• Liver failure (Factor V <30%)
• Thrombopenia < 30 000/mm3 in the absence of planned corrective measures at the time of randomization
• Known or suspected heparin-induced thrombopenia
• Positive blood cultures without treatment or with inappropriate treatment at the time of randomization
• Catheter inserted in the subclavian position
• Person without national health insurance cover
• Pregnant women
• Adults under guardianship