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Today, we know that olfactogustatory alterations occur in cirrhotic patients before the liver transplant but no study has been conducted to show eventual disturbances after the transplantation able to explain modifications in eating behaviour. In parallel, the metabolic status, itself dependent on liver metabolism, influences food preferences and is modified after the transplantation as the liver recovers its ability to store glycogen, but is not able to inform the brain as the afferent nerve impulses have been suppressed. The innovative aspect of this project is to provide information on the importance of the liver in the regulation of energy homeostasis.
The results of this study will improve our understanding of eating behaviour and olfactogustatory sensitivity and allow us to orient liver transplant patients towards appropriate diets.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| liver transplant | Experimental |
| |
| kidney transplant | Active Comparator |
| |
| control | Placebo Comparator |
| |
| stable liver damage | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Respiratory quotient | Other |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Change in respiratory quotient (RQ) by indirect calorimetry compared with baseline values | At month 0, month 3, month 9 and month 15 | |
| Change in olfactory liking compared with baseline values by questionnaire | At month 0, month 3, month 9 and month 15 |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Universitaire | Dijon | 21079 | France |
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| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| ID | Term |
|---|---|
| D001522 | Behavior, Animal |
| D001519 | Behavior |
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| Olfactory liking |
| Other |
|