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ECMO(Extracorporeal membrane oxygenation) is being essential for cardiopulmonary failure patients. There are two types of ECMO, which is veno-veno (V-V) that can be used in respiratory failure patients and veno-arterial (V-A) that can be used in cardiac failure patients. V-A ECMO can also be used during lung transplantation, substitution of cardiopulmonary bypass, which can show sufficient performance during operation and better postoperative outcome. However, regarding V-A ECMO circulating from femoral vein to femoral artery, there is a pro blem of differential hypoxia which might influence coronary artery and head vessels. In this prospective study, the investigators are planning to put another ECMO catheter into internal jugular vein which takes a role of left to right shunt, to mitigate the hypoxia of coronary artery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Veno-veno-arterial ECMO group | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Veno-veno-arterial ECMO | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| arterial blood oxygen partial pressure (PaO2) | 5 min after jugular catheter flow 0ml/min | |
| arterial blood oxygen partial pressure (PaO2) | 5 min after jugular catheter flow 500 ml/min | |
| arterial blood oxygen partial pressure (PaO2) | 5 min after jugular catheter flow 1,000ml/min | |
| arterial blood oxygen partial pressure (PaO2) | 5 min after jugular catheter flow 1,500ml/min |
| Measure | Description | Time Frame |
|---|---|---|
| venous blood oxygen partial pressure (PvO2) | 5 min after jugular catheter flow 0ml/min | |
| venous blood oxygen partial pressure (PvO2) | 5 min after jugular catheter flow 500 ml/min | |
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Inclusion Criteria:
1. scheduled for double lung transplantation
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine | Seoul | 120-752 | South Korea |
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| venous blood oxygen partial pressure (PvO2) |
| 5 min after jugular catheter flow 1,000ml/min |
| venous blood oxygen partial pressure (PvO2) | 5 min after jugular catheter flow 1,500ml/min |
| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D001987 | Bronchiectasis |
| D018192 | Lymphangioleiomyomatosis |
| D065627 | Familial Primary Pulmonary Hypertension |
| D055371 | Acute Lung Injury |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001982 | Bronchial Diseases |
| D008203 | Lymphangiomyoma |
| D018190 | Neoplasm, Lymphatic Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D054973 | Perivascular Epithelioid Cell Neoplasms |
| D018204 | Neoplasms, Connective and Soft Tissue |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D006976 | Hypertension, Pulmonary |
| D055370 | Lung Injury |
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