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The study aims to determine the correlation between the cognitive inhibition impairment and the history of suicide attempt in elderly depressed patients.
2 groups of patients will be studied: in the first group, depressed patients with a history of suicide attempt will be included whereas in the second group, depressed patients without a history of suicide attempt will be included.
For each group, the cognitive inhibition will be assessed trough an eye tracker task (antisaccade).
Both groups will also be compared on their neuropsychological characteristics and the quality of social interactions of participants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| depressed with suicide attempt (SA) | Experimental | elderly depressed patients with a history of suicide attempt. interventions: eye tracking, neuropsychological assessment, psychiatric assessment and sociological interview. |
|
| depressed without a history of SA | Experimental | elderly depressed patients without a history of suicide attempt. interventions: eye tracking, neuropsychological assessment, psychiatric assessment and sociological interview. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| eye tracking | Behavioral | several oculomotor parameters will be recorded using vide-oculography techniques (eye tracking) trough different tasks: saccade, antisaccade, and picture scanning. Saccade task: the patient is looking at a screen and is asked to fix his gaze as quickly and accurately as possible on the red dot appearing on the periphery of the screen. Prosaccade task: the patient is looking at a screen and is asked to fix his gaze as quickly and accurately as possible on the opposite side relative to the red dot appearing on the periphery of the screen. Picture Scanning: participant is instructed to freely watch pictures with different emotional valence. |
| Measure | Description | Time Frame |
|---|---|---|
| antisaccade error rate | 1 month max. after inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| saccade accuracy | distance between the eye position at the end of the first saccade, and the ideal position to engage the target in central vision | 1 month max. after inclusion |
| saccadic intrusion |
| Measure | Description | Time Frame |
|---|---|---|
| neuropsychological test score | 1 month max. after inclusion |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| julie monnin, PhD | Contact | 0033381218543 | jmonnin@chu-besancon.fr | |
| kristina mouyabi | Contact | 0033381218356 | kmouyabi@chu-besancon.fr |
| Name | Affiliation | Role |
|---|---|---|
| pierre vandel, MD PhD | Centre Hospitalier Universitaire de Besancon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Besancon | Recruiting | Besançon | Doubs | 25030 | France |
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| ID | Term |
|---|---|
| D013405 | Suicide |
| D013406 | Suicide, Attempted |
| D003863 | Depression |
| ID | Term |
|---|---|
| D016728 | Self-Injurious Behavior |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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|
| neuropsychological assessement | Behavioral | the neuropsychological assessment aims to identify any impairment of executive functioning through several tasks: Mini mental state examination (mmse), isaac set test (STI) trail making test (TMT A and B), Grober test, Stroop test, verbal fluency, Go No Go task, memory impairment screen (MIS), picture naming test (DO30), copying figure test, digit span and categorical matching test. |
|
| psychiatric assessment | Behavioral | this evaluation aims to characterize the mental status of the patient. Different scales will be used: Montgomery and ASberg depression rating scale (MADRS), Columbia-suicide severity rating scale (C-SSRS), Beck depression inventory (BDI), Barratt impulsiveness scale (BIS-10), Buss and Durkee Hostility Inventory (BDHI), Balloon, analogue risk task (BART), Iowa gambling task (IGT), and Childhood trauma questionnaire (CTQ). |
|
| sociological interview | Behavioral | this interview aims to characterize social interactions of the patients, their duration, their evolution and the perception of each participant on this subject. |
|
gaze deviation into a saccade greater than 3° during visual fixation
| 1 month max. after inclusion |
| maximal speed of the gaze | maximum speed of visual tracking without triggering any saccade | 1 month max. after inclusion |
| saccade reaction time | 1 month max. after inclusion |
| fixation duration on pictures | 1 month max. after inclusion |
| social interaction quality score | 6 month max. after inclusion |
| CHS Bavilliers | Not yet recruiting | Bavilliers | France |
|