The main objective of this study is to compare the efficacy of botulinum toxin injections on vestibulodynia pain compared to a group treated with a placebo.

Inclusion Criteria:

• Subject refractory to conventional treatments (tricyclic antidepressants and benzodiazepines at analgesic doses, biofeedback physical therapy)
• Negative screening test results
• Notified associated factors
• Menopause, surgically sterilized women or women using effective contraceptive method
• Good understanding and predictable adherence to the protocol
• beneficiary/affiliated to French social security/social healthcare
• signed Informed Consent Form

Exclusion Criteria:

• Predictable poor adherence
• Pregnant or breastfeeding women
• Myasthenia
• Treatment with aminoglycosides
• Major mental disorders
• Underlying etiology
• Vulnerable subjects (particularly adults under guardianship)
• Any reason deemed relevant by the investigator
• Current or former (in the last 3 months) participation to another clinical trial