This study evaluates the immune response for patients affected by metastatic breast cancer treated by everolimus

Inclusion Criteria:

• patients eligible for a treatment by everolimus in association with the exemestane
• Performance status of 0,1 or 2 according to the WHO
• Patients affected of a breast cancer advanced and\or metastatic HER2 negative expressing the hormonal receptor RH +
• menopausal Patients

Exclusion Criteria:

• Psychiatric disease compromising the understanding of the information or the realization of the study
• Vulnerable people according to the law (minors, adults under protection, private persons of freedom)
• Histories of cancer in 5 years preceding the diagnosis (except breast cancer, squamous-cell)
• Not menopausal women
• Unaffiliated people to the Social Security
• People being for the period of exclusion from another study
• Hypersensitivity in the active substance, in the other by-products of the rapamycin or in one of the excipients.
• Symptomatic visceral achievement
• Legal incapacity or limited legal capacity