Tumor Response in Hypofractionated Radiotherapy

Biomarkers of Tumor Response in Hypofractionated Radiotherapy

This study will follow-up different immune cell populations in the blood before, during and after high dose radiation therapy which should give new information of the efficacy of Local Hypofractionated Radiotherapy and a rationale for adjuvant immunotherapy.

• Patient information and collection of a signed informed consent form

• Clinical data collection

• Blood samples of 5 mL:

  1. after registration, prior to the first fraction of radiotherapy
  2. during radiotherapy sessions
  3. one month, 3 months after the last radiotherapy session

• Storage of the blood samples at ambient temperature

• Transportation of the samples to the Institute of Biology of Lille (IBL) - CNRS UMR8161 for analysis

• Destruction of the samples at the end of the analysis

Inclusion Criteria:

• Patient requiring a hypofractionated irradiation;
• pathologically confirmed Unspecified Adult Solid Tumor
• Age ≥ 18 years old
• KPS≥70
• Signed written informed consent.

Exclusion Criteria:

• Patient treated by chemotherapy, targeted or immunotherapy within 21 days before the first sampling,
• Pregnant or breastfeeding woman,
• Patient under guardianship or tutorship.