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The purpose of this study is to determine the effect of gender on pharmacodynamic interaction of propofol and dexmedetomidine, exploring the effect of gender on propofol unconsciousness median effective concentration with different dose dexmedetomidine.
60 cases male patients were randomly divided into four groups,and 60 female patients were also randomly divided into four groups.In each group, dexmedetomidine target plasma concentration are 0,0.4,0.6,0.8 ng/ml. Dexmedetomidine administered 15 min before target controlled infusion of propofol. The propofol infusion is started to provide a target effect-site concentration of 1.0 ug/ml, and increased by 0.2 ug/ml until loss of consciousness when the effect-site concentration and target concentration are equilibrium.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propofol and 0.0 ng/ml Dexmedetomidine | Placebo Comparator | Propofol infusion was started to provide an effect-site concentration of 1.0ug/ml after Dexmedetomidine which target plasma concentration is 0.0ng/ml administered for 15min, and increased by 0.2 ug/ml until the patient's consciousness disappears. |
|
| Propofol and 0.4 ng/ml Dexmedetomidine | Experimental | Propofol infusion was started to provide an effect-site concentration of 1.0ug/ml after Dexmedetomidine which target plasma concentration is 0.4ng/ml administered for 15min, and increased by 0.2 ug/ml until the patient's consciousness disappears. |
|
| Propofol and 0.6 ng/ml Dexmedetomidine | Experimental | Propofol infusion was started to provide an effect-site concentration of 1.0ug/ml after Dexmedetomidine which target plasma concentration is 0.6ng/ml administered for 15min, and increased by 0.2 ug/ml until the patient's consciousness disappears. |
|
| Propofol and 0.8 ng/ml Dexmedetomidine | Experimental | Propofol infusion was started to provide an effect-site concentration of 1.0ug/ml after Dexmedetomidine which target plasma concentration is 0.8ng/ml administered for 15min, and increased by 0.2 ug/ml until the patient's consciousness disappears. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0.0 ng/ml Dexmedetomidine | Drug | Dexmedetomidine target plasma concentration is 0.0 ng/ml |
|
| Measure | Description | Time Frame |
|---|---|---|
| the effect-site EC50 of propofol on loss of consciousness with different gender | The aim of the investigators study is to define the optimum target concentration (EC50) of propofol for loss of consciousness with different dexmedetomidine target plasm concentration. | within 30 min during the induction of anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| The EC95 of propofol for loss of consciousness with different gender | The aim of the investigators study is to define the optimum target concentration (EC95) of propofol for loss of consciousness with different dexmedetomidine target plasm concentration. | within 30 min during the induction of anesthesia |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangzhou Military Region General Hospital, Department of Anesthesiology | Guangzhou | Guangdong | 510010 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16037147 | Background | Kodaka M, Johansen JW, Sebel PS. The influence of gender on loss of consciousness with sevoflurane or propofol. Anesth Analg. 2005 Aug;101(2):377-381. doi: 10.1213/01.ANE.0000154534.71371.4F. |
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| ID | Term |
|---|---|
| D003075 | Coitus |
| ID | Term |
|---|---|
| D012725 | Sexual Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| 0.4 ng/ml Dexmedetomidine | Drug | Dexmedetomidine target plasma concentration is 0.4 ng/ml |
|
| 0.6 ng/ml Dexmedetomidine | Drug | Dexmedetomidine target plasma concentration is 0.6 ng/ml |
|
| 0.8 ng/ml Dexmedetomidine | Drug | Dexmedetomidine target plasma concentration is 0.8 ng/ml |
|
| Propofol | Drug | The propofol infusion was started to provide an effect-site concentration of 1.0 ug/ml, and increased by 0.2 ug/ml until loss of consciousness |
|
| D010636 |
| Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |