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| Name | Class |
|---|---|
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
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Anhedonia and avolition reflect emotional and motivational disorders, respectively. However, if these disorders play a major role in the symptomatology of schizophrenia, their mechanisms remain poorly understood, and existing treatments are inefficient on these symptoms. The literature suggests that the impairment does not concern emotion or motivation per se, but rather their influence on cognition. This project aims at using recent advances in the fundamental domain to better understand the cognitive and neuronal mechanisms of the patients' alterations, and especially how emotion and motivation influence cognition in schizophrenia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | Sham Comparator | Healthy volunteers |
|
| Patients with schizophrenia | Experimental | Patients with schizophrenia |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Electroencephalogram | Other | electrophysiological measurements (evoked potentials) based on neural activity when visualizing stimuli |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in the amplitude of the CNV (Contingent Negative Variation) as a function of the primer displayed on the screen | Before each cognitive trial a primer will be displayed, which will be either neutral or convey emotion or motivation. The investigators will check whether this primer affects the subjects preparation by measuring the CNV, which is an evoked potential recorded with electroencephalography, and indexing preparatory effort. | During EEG sessions, at experimental session 1 (Day 0) and experimental session 2 (up to Day 120) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in the amplitude of the LPP (Late Positive Potential) as a function of the primer displayed on the screen | The investigators will check whether primers affect the subjects attention by measuring the LPP, which is an evoked potential recorded with electroencephalography, and indexing sustained attention. | During EEG sessions, at experimental session 1 (Day 0) and experimental session 2 (up to Day 120) |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Unité INSERM 1114 | Strasbourg | 67091 | France |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| Cognitive tasks | Behavioral | - clinical scales and subjective assessments of emotional and motivational stimuli |
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| subjective evaluation scales | Behavioral | - clinical scales and subjective assessments of emotional and motivational stimuli |
|