One-step Nucleic Acid Amplification for Detecting Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma

Etude de Concordance Entre la Technique OSNA et Les Techniques Classiques Pour la Recherche de métastases Ganglionnaires Des Cancers Des VADS

The investigators main objective is to show that OSNA technique is as accurate as pathological analysis (frozen section / HE staining and immunochemistry) to detect occult lymph node metastasis (micro and macrometastasis).

Inclusion Criteria:

• Patient > 18 years old
• Head and neck squamous cell carcinoma diagnosed by biopsy
• N0 classification (N0: no lymph node invasion on clinical and radiological examination).
• Neck dissection or sentinel lymph node biopsy required to treat the patient
• ECOG 1,2 or 3
• Patient's consent

Exclusion Criteria:

• Patient previously treated by radiotherapy or surgery for head and neck neoplasm.
• Contraindication or patient unwillingness to undergo surgical treatment
• Incapacitated adults